Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround
specific neurons in the brain and spinal cord, appear during critical periods of development …

Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

Although decades of research have shown associations between early caregiving adversity,
stress physiology and limbic brain volume (eg, amygdala, hippocampus), the developmental …

The medial prefrontal cortex (mPFC) receives information regarding stimuli and
appropriately orchestrates neurophysiological, autonomic, and behavioral responses to …

The early life period represents a window of increased vulnerability to stress, during which
exposure can lead to long-lasting effects on brain structure and function. This stress-induced …

Mice socially isolated during adolescence exhibit behaviors of anxiety, depression and
impaired social interaction. Although these behaviors are well documented, very little is …

It is increasingly evident that cells and molecules of the immune system play significant roles
in neurodevelopment. As perinatal infection is associated with the development of …

Severe stress is among the most robust risk factors for the development of psychiatric
disorders. Imaging studies indicate that life stress is integral to shaping the human brain …

Background Alterations in the structure and physiology of interneurons in the prefrontal
cortex (PFC) are important factors in the etiopathology of different psychiatric disorders …

Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures regulating
developmental plasticity and protecting neurons against oxidative stress. PNN abnormalities …