Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Visceral pain is a global term used to describe pain originating from the internal organs of
the body, which affects a significant proportion of the population and is a common feature of …

The gut microbiota has been implicated in chronic pain disorders, including irritable bowel
syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed …

Background & Aims Altered gut microbiota composition and function have been associated
with inflammatory bowel diseases, including ulcerative colitis (UC), but the causality and …

For decades, interactions between the enteric neuromuscular apparatus and the central
nervous system have served as the primary focus of pathophysiological research in the …

It is increasingly perceived that gut host–microbial interactions are important elements in the
pathogenesis of functional gastrointestinal disorders (FGID). The most convincing evidence …

Bidirectional signalling between the gastrointestinal tract and the brain is regulated at
neural, hormonal, and immunological levels. This construct is known as the brain–gut axis …

Background & Aims Histamine sensitizes the nociceptor transient reporter potential channel
V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals. We …

Alterations in the bidirectional interactions between the intestine and the nervous system
have important roles in the pathogenesis of irritable bowel syndrome (IBS). A body of largely …

Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints
arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity …