Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

JL Wallace, R Wang - Nature reviews Drug discovery, 2015 - nature.com
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …

Hydrogen sulfide in biochemistry and medicine

BL Predmore, DJ Lefer, G Gojon - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: An abundance of experimental evidence suggests that hydrogen sulfide (H2S)
plays a prominent role in physiology and pathophysiology. Many targets exist for H2S …

Highly selective fluorescent probe design for visualizing hepatic hydrogen sulfide in the pathological progression of nonalcoholic fatty liver

W Li, Y Shen, X Gong, XB Zhang, L Yuan - Analytical Chemistry, 2021 - ACS Publications
Hydrogen sulfide (H2S), emerging as an important gaseous signal, has attracted more and
more attention for its key role in chronic fatty liver diseases. However, lacking tools for H2S …

Hydrogen sulfide and the liver

S Mani, W Cao, L Wu, R Wang - Nitric Oxide, 2014 - Elsevier
Hydrogen sulfide (H 2 S) is a gasotransmitter that regulates numerous physiological and
pathophysiological processes in our body. Enzymatic production of H 2 S is catalyzed by …

The liver as a central regulator of hydrogen sulfide

EJ Norris, CR Culberson, S Narasimhan, MG Clemens - Shock, 2011 - journals.lww.com
The liver is likely exposed to high levels of hydrogen sulfide (H 2 S) from endogenous
hepatic synthesis and exogenous sources from the gastrointestinal tract. Little is known …

Hydrogen sulfide as a novel regulatory factor in liver health and disease

DD Wu, DY Wang, HM Li, JC Guo… - … medicine and cellular …, 2019 - Wiley Online Library
Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been recognized as
a toxic gas and environment pollutant. However, increasing evidence suggests that H2S …

Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats

G Tan, S Pan, J Li, X Dong, K Kang, M Zhao, X Jiang… - PloS one, 2011 - journals.plos.org
Background Hydrogen sulfide (H2S) displays vasodilative, anti-oxidative, anti-inflammatory
and cytoprotective activities. Impaired production of H2S contributes to the increased …

Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity

AA Fouad, I Jresat - Environmental toxicology and pharmacology, 2012 - Elsevier
The potential protective effect of coenzyme Q10 against acute liver injury induced by a
single dose of acetaminophen (700mg/kg, po) was investigated in rats. Coenzyme Q10 …

Role of Hydrogen Sulfide in Oncological and Non-oncological disorders and its regulation by non-coding RNAs: a Comprehensive Review

RA Youness, DA Habashy, N Khater, K Elsayed… - Non-coding RNA, 2024 - mdpi.com
Recently, myriad studies have defined the versatile abilities of gasotransmitters and their
synthesizing enzymes to play a “Maestro” role in orchestrating several oncological and non …