Lyme disease pathogenesis
Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …
Gene regulation and transcriptomics
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …
Disulfiram (Tetraethylthiuram Disulfide) in the treatment of lyme disease and babesiosis: report of experience in three cases
KB Liegner - Antibiotics, 2019 - mdpi.com
Three patients, each of whom had required intensive open-ended antimicrobial therapy for
control of the symptoms of chronic relapsing neurological Lyme disease and relapsing …
control of the symptoms of chronic relapsing neurological Lyme disease and relapsing …
Superior efficacy of combination antibiotic therapy versus monotherapy in a mouse model of Lyme disease
Y Alruwaili, MB Jacobs, NR Hasenkampf… - Frontiers in …, 2023 - frontiersin.org
Lyme disease (LD) results from the most prevalent tick-borne infection in North America, with
over 476,000 estimated cases annually. The disease is caused by Borrelia burgdorferi (Bb) …
over 476,000 estimated cases annually. The disease is caused by Borrelia burgdorferi (Bb) …
Repurposing Disulfiram (Tetraethylthiuram Disulfide) as a Potential Drug Candidate against Borrelia burgdorferi In Vitro and In Vivo
Lyme disease caused by the Borrelia burgdorferi (Bb or B. burgdorferi) is the most common
vector-borne, multi-systemic disease in the USA. Although most Lyme disease patients can …
vector-borne, multi-systemic disease in the USA. Although most Lyme disease patients can …
Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening
VR Pothineni, D Wagh, MM Babar… - Drug Design …, 2016 - Taylor & Francis
Lyme disease is the most common zoonotic bacterial disease in North America. It is
estimated that> 300,000 cases per annum are reported in USA alone. A total of 10%–20% of …
estimated that> 300,000 cases per annum are reported in USA alone. A total of 10%–20% of …
“Repurposing” disulfiram in the treatment of Lyme disease and babesiosis: retrospective review of first 3 years' experience in one medical practice
J Gao, Z Gong, D Montesano, E Glazer, K Liegner - Antibiotics, 2020 - mdpi.com
A total of 71 patients with Lyme disease were identified for analysis in whom treatment with
disulfiram was initiated between 15 March 2017 and 15 March 2020. Four patients were lost …
disulfiram was initiated between 15 March 2017 and 15 March 2020. Four patients were lost …
Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31
Lyme disease is one of most common vector-borne diseases, reporting more than 300,000
cases annually in the United States. Treating Lyme disease during its initial stages with …
cases annually in the United States. Treating Lyme disease during its initial stages with …
Contribution of a ZIP‐family protein to manganese uptake and infective endocarditis virulence in Streptococcus sanguinis
Streptococcus sanguinis is an important cause of infective endocarditis. In strain SK36, the
ABC‐family manganese transporter, SsaACB, is essential for virulence. We have now …
ABC‐family manganese transporter, SsaACB, is essential for virulence. We have now …
Current and emerging approaches for eliminating Borrelia burgdorferi and alleviating persistent Lyme disease symptoms
Lyme disease is the most prevalent tick-borne infection caused by Borrelia burgdorferi
bacteria in North America. Other Borrelia species are predominately the cause of this …
bacteria in North America. Other Borrelia species are predominately the cause of this …