Fixation can change the appearance of phase separation in living cells
Fixing cells with paraformaldehyde (PFA) is an essential step in numerous biological
techniques as it is thought to preserve a snapshot of biomolecular transactions in living cells …
techniques as it is thought to preserve a snapshot of biomolecular transactions in living cells …
Mitotic bookmarking redundancy by nuclear receptors in pluripotent cells
A Chervova, A Molliex, HI Baymaz, RX Coux… - Nature Structural & …, 2024 - nature.com
Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate
reactivation after mitotic gene silencing. However, the loss of individual bookmarking TFs …
reactivation after mitotic gene silencing. However, the loss of individual bookmarking TFs …
Transcription factor retention on mitotic chromosomes: regulatory mechanisms and impact on cell fate decisions
M Raccaud, DM Suter - FEBS letters, 2018 - Wiley Online Library
During mitosis, gene transcription stops, and the bulk of DNA‐binding proteins are excluded
from condensed chromosomes. While most gene‐specific transcription factors are largely …
from condensed chromosomes. While most gene‐specific transcription factors are largely …
A role for mitotic bookmarking of SOX2 in pluripotency and differentiation
Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and
were proposed to regulate phenotypic maintenance of stem and progenitor cells at the …
were proposed to regulate phenotypic maintenance of stem and progenitor cells at the …
Mitotic chromosome binding predicts transcription factor properties in interphase
Mammalian transcription factors (TFs) differ broadly in their nuclear mobility and sequence-
specific/non-specific DNA binding. How these properties affect their ability to occupy specific …
specific/non-specific DNA binding. How these properties affect their ability to occupy specific …
Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation
Our previous findings indicated that androgen receptor (AR) phosphorylation at serine 81 is
stimulated by the mitotic cyclin-dependent kinase 1 (CDK1). In this report, we extended our …
stimulated by the mitotic cyclin-dependent kinase 1 (CDK1). In this report, we extended our …
Mitotic genome-bookmarking by nuclear hormone receptors: A novel dimension in epigenetic reprogramming and disease assessment
Arrival of multi-colored fluorescent proteins and advances in live cell imaging has
immensely contributed to our understanding of intracellular trafficking of nuclear receptors …
immensely contributed to our understanding of intracellular trafficking of nuclear receptors …
Friend or foe? Deciphering androgen receptor action to improve bipolar androgen therapy for prostate cancer
SPG Rollin, MG Lawrence… - Endocrine-Related …, 2025 - erc.bioscientifica.com
Inhibiting the activity of the androgen receptor (AR) is the cornerstone treatment for
advanced prostate cancer. AR-targeted therapies are highly effective in slowing disease …
advanced prostate cancer. AR-targeted therapies are highly effective in slowing disease …
Mitotic genome bookmarking by nuclear receptor VDR advocates transmission of cellular transcriptional memory to progeny cells
Mitosis is an essential process for the self-renewal of cells that is accompanied by dynamic
changes in nuclear architecture and chromatin organization. Despite all the changes, the …
changes in nuclear architecture and chromatin organization. Despite all the changes, the …
Cell-cycle-dependent regulation of androgen receptor function
Y Koryakina, KE Knudsen… - Endocrine-related cancer, 2015 - erc.bioscientifica.com
The androgen receptor (AR) is a critical oncogene in prostate cancer (PCa) development
and progression. In this study, we demonstrate cell-cycle-dependent regulation of AR …
and progression. In this study, we demonstrate cell-cycle-dependent regulation of AR …