The BH3-only proteins of Bcl-2 family are essential initiators of apoptosis that propagate
extrinsic and intrinsic cell death signals. The interaction of BH3-only proteins with other Bcl-2 …

Abstract Until 1972, the term 'apoptosis' was used to differentiate the programmed cell death
that naturally occurs in organismal development from the acute tissue death referred to as …

TGF-β signaling can be pro-tumorigenic or tumor suppressive. We investigated this duality in
pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers …

According to the World Health Organization (WHO), cancer is a leading cause of death
worldwide. The identification of novel targets for cancer treatment is an area of intense work …

Combinations of MAP/ERK kinase (MEK) and phosphoinositide 3-kinase (PI3K) inhibitors
have shown promise in preclinical cancer models, leading to the initiation of clinical trials …

Macroautophagy serves cellular housekeeping and metabolic functions through delivery of
cytoplasmic constituents for lysosomal degradation. In addition, it may mediate the …

Summary miR-133a and miR-1 are known as muscle-specific microRNAs that are involved
in cardiac development and pathophysiology. We have shown that both miR-1 and miR …

The family of hexokinases (HKs) catalyzes the first step of glycolysis, the ATP-dependent
phosphorylation of glucose to glucose-6-phosphate. While HK1 and HK2 are ubiquitously …

The dysregulation of apoptosis is a key step in developing tumours, and mediates resistance
to cancer therapy. Many different signals for cell death converge on permeabilization of the …

Ribosome biogenesis and protein synthesis are dysregulated in many cancers, with those
driven by the proto-oncogene c-MYC characterized by elevated Pol I–mediated ribosomal …