Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

Mesenchymal stem cells and immunomodulation: current status and future prospects

F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Mesenchymal stromal cell apoptosis is required for their therapeutic function

SHM Pang, J D'Rozario, S Mendonca, T Bhuvan… - Nature …, 2021 - nature.com
Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …

Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells

SFH de Witte, F Luk, JM Sierra Parraga, M Gargesha… - stem cells, 2018 - academic.oup.com
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential
immunotherapy. MSC are usually administered via intravenous infusion, after which they are …

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

M Madrigal, KS Rao, NH Riordan - Journal of translational medicine, 2014 - Springer
The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the
early paradigm of cell replacement and differentiation as a therapeutic mechanism of action …

The critical role of apoptosis in mesenchymal stromal cell therapeutics and implications in homeostasis and normal tissue repair

C Giacomini, C Granéli, R Hicks, F Dazzi - Cellular & Molecular …, 2023 - nature.com
Mesenchymal stromal cells (MSCs) have been extensively tested for the treatment of
numerous clinical conditions and have demonstrated good safety but mixed efficacy …

Multipotent mesenchymal stromal cells and the innate immune system

K Le Blanc, D Mougiakakos - Nature Reviews Immunology, 2012 - nature.com
Multipotent mesenchymal stromal cells (MSCs) have unique immunoregulatory and
regenerative properties that make them an attractive tool for the cellular treatment of …

How mesenchymal stem cells interact with tissue immune responses

Y Shi, J Su, AI Roberts, P Shou, AB Rabson… - Trends in immunology, 2012 - cell.com
Mesenchymal stem cells (MSCs), also called multipotent mesenchymal stromal cells, exist in
almost all tissues and are a key cell source for tissue repair and regeneration. Under …

Mechanisms of mesenchymal stromal cell immunomodulation

K English - Immunology and cell biology, 2013 - Wiley Online Library
Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the
fields of regenerative medicine, cell therapy and immune modulation. Over the past 5 years …

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

SM Melief, E Schrama, MH Brugman… - Stem …, 2013 - academic.oup.com
Multipotent stromal cells (MSC) have been shown to possess immunomodulatory capacities
and are therefore explored as a novel cellular therapy. One of the mechanisms through …