Dissecting the relationship between neuropsychiatric and neurodegenerative disorders
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …
common causes of death in elderly people, which includes progressive neuronal cell death …
DNMT1: catalytic and non-catalytic roles in different biological processes
KN Mohan - Epigenomics, 2022 - Taylor & Francis
DNMT1 is the main enzyme that uses the information on DNA methylation patterns in the
parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA …
parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA …
Dysregulation of schizophrenia-associated genes and genome-wide hypomethylation in neurons overexpressing DNMT1
S Saxena, S Choudhury, PA Maroju, A Anne… - …, 2021 - Taylor & Francis
Aim: To study the effects of DNMT1 overexpression on transcript levels of genes
dysregulated in schizophrenia and on genome-wide methylation patterns. Materials & …
dysregulated in schizophrenia and on genome-wide methylation patterns. Materials & …
L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development
MR Baker, AS Lee, AM Rajadhyaksha - Channels, 2023 - Taylor & Francis
Recent human genetic studies have linked a variety of genetic variants in the CACNA1C
and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not …
and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not …
Genome-wide methylation analysis of post-mortem cerebellum samples supports the role of peroxisomes in autism spectrum disorder
Aim: We tested the hypothesis that a subset of patients with autism spectrum disorder (ASD)
contains candidate genes with high DNA methylation differences (effective values) that …
contains candidate genes with high DNA methylation differences (effective values) that …
Distinctive Patterns of 5-Methylcytosine and 5-Hydroxymethylcytosine in Schizophrenia
J Xie, Y Wang, C Ye, XJ Li, L Lin - International Journal of Molecular …, 2024 - mdpi.com
Schizophrenia is a highly heritable neuropsychiatric disorder characterized by cognitive and
social dysfunction. Genetic, epigenetic, and environmental factors are together implicated in …
social dysfunction. Genetic, epigenetic, and environmental factors are together implicated in …
DNMT1 downregulation as well as its overexpression distinctly affect mostly overlapping genes implicated in schizophrenia, autism spectrum, epilepsy, and bipolar …
Data on schizophrenia (SZ), epilepsy (EPD) and bipolar disorders (BPD) suggested an
association of DNMT1 overexpression whereas certain variants of the gene were predicted …
association of DNMT1 overexpression whereas certain variants of the gene were predicted …
DNMT1 Y495C mutation interferes with maintenance methylation of imprinting control regions
Abstract Hereditary Sensory and Autonomic Neuropathy Type 1E (HSAN1E) is a rare
autosomal dominant neurological disorder due to missense mutations in DNA …
autosomal dominant neurological disorder due to missense mutations in DNA …
DNA 甲基化与精神分裂症的研究进展
尹文卅， 卢玉梅， 佟金莲， 聂胜洁， 阮冶 - 昆明医科大学学报, 2023 - kyxuebao.kmmu.edu.cn
精神分裂症是一种以认知, 思维, 情感, 行为等多方面显著异常为特征的精神疾病,
是最常见的重性精神疾病之一, 给个人, 家庭以及社会带来严重困扰. 近年来针对精神分裂症患者 …
是最常见的重性精神疾病之一, 给个人, 家庭以及社会带来严重困扰. 近年来针对精神分裂症患者 …
DNMT1-Mediated Regulation of Inhibitory Interneuron Migration Impacts Cortical Architecture and Function
J Reichard, P Wolff, J Du, CL Fullio, L Dorp, CB Yildiz… - bioRxiv, 2024 - biorxiv.org
The fine-tuned establishment of neuronal circuits during the formation of the cerebral cortex
is pivotal for its functionality. Developmental abnormalities affecting the composition of …
is pivotal for its functionality. Developmental abnormalities affecting the composition of …