[HTML][HTML] Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

S Halldorsson, E Lucumi, R Gómez-Sjöberg… - Biosensors and …, 2015 - Elsevier
Culture of cells using various microfluidic devices is becoming more common within
experimental cell biology. At the same time, a technological radiation of microfluidic cell …

[HTML][HTML] New perspectives: In-situ tissue engineering for bone repair scaffold

S Cao, Y Zhao, Y Hu, L Zou, J Chen - Composites Part B: Engineering, 2020 - Elsevier
This review explores state-of-the-art and new perspectives description of scaffold-based
strategies utilized in in-suit bone tissue engineering. The bone defects caused by severe …

Biological detection by optical oxygen sensing

DB Papkovsky, RI Dmitriev - Chemical Society Reviews, 2013 - pubs.rsc.org
Recent developments in the area of biological detection by optical sensing of molecular
oxygen (O2) are reviewed, with particular emphasis on the quenched-phosphorescence O2 …

Organs-on-chips: breaking the in vitro impasse

AD Van Der Meer, A Van Den Berg - Integrative Biology, 2012 - academic.oup.com
In vitro models of biological tissues are indispensable tools for unraveling human physiology
and pathogenesis. They usually consist of a single layer of a single cell type, which makes …

Oxygen control with microfluidics

MD Brennan, ML Rexius-Hall, LJ Elgass… - Lab on a Chip, 2014 - pubs.rsc.org
Cellular function and behavior are affected by the partial pressure of O2, or oxygen tension,
in the microenvironment. The level of oxygenation is important, as it is a balance of oxygen …

Integration and application of optical chemical sensors in microbioreactors

P Gruber, MPC Marques, N Szita, T Mayr - Lab on a Chip, 2017 - pubs.rsc.org
The quantification of key variables such as oxygen, pH, carbon dioxide, glucose, and
temperature provides essential information for biological and biotechnological applications …

An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids

T Anada, J Fukuda, Y Sai, O Suzuki - Biomaterials, 2012 - Elsevier
Since oxygen is one of the critical limiting factors for maintaining cell viability and function, a
great deal of effort is being focused on improving the oxygen supply to three-dimensional …

Microfluidic organ-on-a-chip devices for liver disease modeling in vitro

P Kanabekova, A Kadyrova, G Kulsharova - Micromachines, 2022 - mdpi.com
Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …

[HTML][HTML] A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices

SA Mousavi Shaegh, F De Ferrari, YS Zhang… - …, 2016 - pubs.aip.org
There is a growing interest to develop microfluidic bioreactors and organ-on-chip platforms
with integrated sensors to monitor their physicochemical properties and to maintain a well …

Engineered skeletal muscles for disease modeling and drug discovery

J Wang, A Khodabukus, L Rao, K Vandusen… - Biomaterials, 2019 - Elsevier
Skeletal muscle is the largest organ of human body with several important roles in everyday
movement and metabolic homeostasis. The limited ability of small animal models of muscle …