Investigating the role of peptides in effective therapies against cancer

R Naeimi, A Bahmani, S Afshar - Cancer Cell International, 2022 - Springer
Early diagnosis and effective treatment of cancer are challenging. To diagnose and treat
cancer effectively and to overcome these challenges, fundamental innovations in traditional …

Identification of key genes in colorectal cancer diagnosis by weighted gene co-expression network analysis

M Mortezapour, L Tapak, F Bahreini, R Najafi… - Computers in Biology …, 2023 - Elsevier
Background The purpose of this study was using bioinformatics tools to identify biomarkers
and molecular factors involved in the diagnosis of colorectal cancer, which are effective for …

Using machine learning approach for screening metastatic biomarkers in colorectal cancer and predictive modeling with experimental validation

A Ahmadieh-Yazdi, A Mahdavinezhad, L Tapak… - Scientific Reports, 2023 - nature.com
Colorectal cancer (CRC) liver metastasis accounts for the majority of fatalities associated
with CRC. Early detection of metastasis is crucial for improving patient outcomes but can be …

A review of recent advances in peptide-based anticancer therapeutic vaccines and nanovaccines in prostate cancer

A Khezrian, M Ahmadi, P Mokarram, S Afshar… - International Journal of …, 2023 - Springer
Immunotherapy is a critical component of treating various malignancies. So far, there have
been numerous attempts to cure prostate cancer operating diverse types of immunotherapy …

Lansoprazole as a potent HDAC2 inhibitor for treatment of colorectal cancer: An in-silico analysis and experimental validation

S Khadempar, M Lotfi, F Haghiralsadat… - Computers in Biology …, 2023 - Elsevier
Abstract Background Histone deacetylase 2 (HDAC2), belonging to the class I HDAC family,
holds significant therapeutic potential as a crucial target for diverse cancer types. As key …

Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis

Y Yang, Z Zeng, L Li, S Lei, Y Wu, T Chen… - Cancer Biology & …, 2023 - Taylor & Francis
Sinapine thiocyanate (ST), an alkaloid existed extensively in seeds of cruciferous plants,
exhibits a number of pharmacological effects, including anti-inflammatory and anti …

TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach

T Cheraghi-Shavi, R Jalal, Z Minuchehr - PLoS One, 2023 - journals.plos.org
Acquired resistance to oxaliplatin is considered as the primary reason for failure in colorectal
cancer (CRC) therapy. Identifying the underlying resistance mechanisms may improve CRC …

Introducing novel key genes and transcription factors associated with rectal cancer response to chemoradiation through co-expression network analysis

S Afshar, T Leili, P Amini, I Dinu - Heliyon, 2023 - cell.com
Preoperative radiochemotherapy is a promising therapeutic method for locally advanced
rectal cancer patients. However, the response of colorectal cancer (CRC) patients to …

N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells

J Lai, Z Zhou, K Hu, HL Yu, X Su, X Niu, H Li, S Mao - Epigenetics, 2024 - Taylor & Francis
ABSTRACT N6 methyladenosine (m6A), methylation at the sixth N atom of adenosine, is the
most common and abundant modification in mammalian mRNAs and non-coding RNAs …

Ganoderic acid T improves the radiosensitivity of HeLa cells via converting apoptosis to necroptosis

CS Shao, N Feng, S Zhou, XX Zheng… - Toxicology …, 2021 - academic.oup.com
The use of natural substances derived from traditional Chinese medicine and natural plants
as safe radiosensitizing adjuvants is a new trend for cancer radiotherapy. Ganoderma …