Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin
resistance in which oxidative stress is thought to be a primary cause. Considering that …

Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring
when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2 …

Oxidative stress results from the disruption of the redox system marked by a notable
overproduction of reactive oxygen species. There are four major sources of reactive oxygen …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Oxidative cellular damage caused by free radicals is known to contribute to the
pathogenesis of various diseases such as cancer, diabetes, and neurodegenerative …

The objective of this study was to evaluate the neuroprotective effect of sitagliptin (Sita),
quercetin (QCR) and its combination in β‐amyloid (Aβ) induced Alzheimer's disease (AD) …

Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause
of end-stage renal disease (ESRD) worldwide. Currently, there are limited therapeutic drugs …

Allisartan isoproxil is a new nonpeptide angiotensin II receptor blocker (ARB) precursor drug
that is used to treat hypertension and reduce the risk of heart disease. The present study …

The incidence of type 2 diabetes mellitus (T2DM), the most prevalent metabolic disease, is
rapidly growing worldwide. T2DM has several underlying causes involved in its …