Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Skeletal muscle atrophy is the consequence of protein degradation exceeding protein
synthesis. This arises for a multitude of reasons including the unloading of muscle during …

Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part
of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer …

The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly
understood due to limited samples or targeted genes in current studies. Here, we perform …

Mitochondria are the critical organelles involved in various cellular functions. Mitochondrial
biogenesis is activated by multiple cellular mechanisms which require a synchronous …

We investigated the role of mitochondrial function in the invasiveness of human colorectal
cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and …

Recent Advances: Various studies have suggested that mitochondrial DNA copy number
(mtDNA-CN), a surrogate biomarker of mitochondrial dysfunction, is an easily quantifiable …

Colorectal cancer (CRC) is among the most frequent cancer entities worldwide. Multiple
factors are causally associated with CRC development, such as genetic and epigenetic …

Mitochondrial DNA plays a critical role in the pathophysiology of cancer. However, the
associations between mitochondrial DNA copy number (mtDNA‐CN) and cancer risk are …

The current standard for molecular profiling of colorectal cancer (CRC) is using resected or
biopsied tissue specimens. However, they are limited regarding sampling frequency …