Antioxidant and anti-apoptotic potency of allicin and lycopene against methotrexate-induced cardiac injury in rats
This study aimed to explore whether allicin (ALC) and lycopene (LP) could offer protection
against the harmful effects of methotrexate (MTX), a type of chemotherapy drug known for its …
against the harmful effects of methotrexate (MTX), a type of chemotherapy drug known for its …
[PDF][PDF] Allicin and Lycopene Possesses a Protective Effect against Methotrexate-induced Testicular Toxicity in Rats.
Methotrexate (MTX) is a chemotherapeutic medicine frequently used to treat various forms of
cancer. The objective of our research was to examine whether allicin (ALC) and lycopene …
cancer. The objective of our research was to examine whether allicin (ALC) and lycopene …
Modulatory effect of amifostine (WR-1065) against genotoxicity and oxidative stress induced by methotrexate in human umbilical vein endothelial cells (HUVECs)
S Aghajanshakeri, A Salmanmahiny… - Toxicology …, 2023 - Taylor & Francis
Amifostine is used in chemotherapy and radiotherapy as a cytoprotective adjuvant alongside
DNA-binding chemotherapeutic agents. It functions by reducing free radicals and detoxifying …
DNA-binding chemotherapeutic agents. It functions by reducing free radicals and detoxifying …
A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms
A Nagy, D Börzsei, A Hoffmann, S Török… - … Drugs and Therapy, 2024 - Springer
While oncotherapy has made rapid progress in recent years, side effects of anti-cancer
drugs and treatments have also come to the fore. These side effects include cardiotoxicity …
drugs and treatments have also come to the fore. These side effects include cardiotoxicity …
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats
Type 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease, especially
myocardial injury. Due to their hypoglycemic effects, glucagon-like peptide-1 receptor …
myocardial injury. Due to their hypoglycemic effects, glucagon-like peptide-1 receptor …
Augmented nephroprotective effect of liraglutide and rabeprazole via inhibition of OCT2 transporter in cisplatin-induced nephrotoxicity in rats
G Sharaf, EM El Morsy, EK El-Sayed - Life Sciences, 2023 - Elsevier
Aims Cisplatin, a widely used anticancer treatment, has a marked nephrotoxic effect. This
nephrotoxic effect is linked to the triggering of oxidative stress, inflammation, activation of …
nephrotoxic effect is linked to the triggering of oxidative stress, inflammation, activation of …
Taurine and enzymatically modified isoquercitrin protected against methotrexate‐induced deteriorations in the conductivity and rhythmicity of the heart in rats …
MM Mahmoud, SA El‐Batran, R Hegazy… - Journal of Applied …, 2024 - Wiley Online Library
Cardiotoxicity is one of the most devastating complications of cancer treatment by
methotrexate (MTX). The present study aimed to investigate the potential anti‐cardiotoxic …
methotrexate (MTX). The present study aimed to investigate the potential anti‐cardiotoxic …
Leflunomide-induced cardiac injury in adult male mice and bioinformatic approach identifying Nrf2/NF-κb signaling interplay
AA Rahman, A Hegazy, LM Elabbasy… - Toxicology …, 2024 - Taylor & Francis
Leflunomide (LFND) is an immunosuppressive and immunomodulatory disease-modifying
antirheumatic drug (DMARD) that was approved for treating rheumatoid arthritis. LFND …
antirheumatic drug (DMARD) that was approved for treating rheumatoid arthritis. LFND …
Taurine and enzymatically modified isoquercitrin synergistically protect against the methotrexate-induced cardiotoxicity in rats: antioxidant and antiapoptotic effects
MM Mahmoud, R Hegazy… - Drug and Chemical …, 2024 - Taylor & Francis
This study aimed to evaluate the protective potential of taurine (Tau) and enzymatically
modified isoquercitrin (EMIQ), both individually and in combination, against MTX-induced …
modified isoquercitrin (EMIQ), both individually and in combination, against MTX-induced …
[HTML][HTML] Effect of vitamin B12 on methotrexate-induced cardiotoxicity in rats
Objective (s): Methotrexate (MTX) is a drug with anti-inflammatory and immunosuppressive
effects and is also a folic acid antagonist. Our aim in this study is to determine the molecular …
effects and is also a folic acid antagonist. Our aim in this study is to determine the molecular …