Hepatitis C virus (HCV) infection has become a global health problem with enormous risks.
Nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) is a component …

Vaccination stands alone as an unparalleled medical intervention able to save human lives
numbering hundreds of millions. Modern licensed vaccines are either whole organism …

Aims Deguelin, a natural compound derived from Mundulea sericea (Leguminosae) and
some other plants exhibits an activity to inhibit autophagy, a cellular machinery required for …

A successful viral infection is due to the effective evasion of viruses of the immune system.
The entry of viruses is usually detected by different cellular receptors including PRRs …

Drug resistance mutations (DRMs) may reduce the efficacy of antiviral therapy. However, the
studies focused on naturally occurring, pre‐existing DRMs among co‐infected patients in …

Direct-acting antivirals (DAAs) revolutionized treatment of hepatitis C virus (HCV) infection.
Resistance-associated substitutions (RASs) present at the baseline impair response to DAA …

Despite the hope that was raised with the implementation of antibiotics to the treatment of
infections in medical practice, the initial enthusiasm has substantially faded due to …

目的观察应用阿舒瑞韦(ASV) 联合达拉他韦(DCV) 治疗慢性丙型肝炎(CHC)
或代偿期丙型肝炎肝硬化患者的初步疗效, 并分析复发患者丙型肝炎病毒(HCV) …

Currently, direct-acting antiviral drugs (DAAs) are widely used as therapeutic methods for
hepatitis C virus (HCV)-positive patients, however, patients may experience treatment …

Hepatitis C virus (HCV) remains a global public health problem with high prevalence rates
and chronicity of infection. Present work aimed to describe the main mutations in the NS3 …