The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Maintaining normal hemostasis relies on a regulated system of procoagulant and
anticoagulant pathways, and disruption of these processes leads to the loss of hemostatic …

Critically ill patients with COVID-19 pneumonia suffered both high thrombotic and bleeding
risk. The effect of SARS-CoV-2 on coagulation and fibrinolysis is not well known. We …

Accurate assessment of blood haemostasis is essential for the management of patients who
use extracorporeal devices, receive anticoagulation therapy or experience coagulopathies …

Clinical response to bypassing agents (BPAs) may vary between patients. Surgery is a
particular situation, requiring effective hemostasis during the procedure and for several days …

Understanding the mechanism of action of normal hemostasis and how the bypassing
agents recombinant activated factor VII (rFVIIa; NovoSeven) and plasma‐derived activated …

Commercial assays for determining thrombin generation in plasma are being tested in
clinical conditions associated with thrombosis or bleeding. While pre-analytical conditions …

Background Severe postpartum hemorrhage (PPH), defined as a blood loss≥ 1000 mL, is
associated with maternal morbidity and mortality. Objectives We aimed at characterizing …

Clot waveform analysis (CWA) is a recently developed global coagulation assessment,
based on the continuous observation of changes in light transmittance, absorbance, or light …

Uncontrolled bleeding from traumatic injury remains the leading cause of preventable death
with loss of balance between blood clotting (coagulation) and blood clot breakdown …