Data mining has been recognized by many researchers as a hot topic in different areas. In the post-genomic era, the growing number of sequences deposited in databases has been …
Antimicrobial peptides (AMPs) seem to be promising alternatives to common antibiotics, which are facing increasing bacterial resistance. Among them are the cysteine-stabilized αβ …
The antimicrobial peptides (AMP) have been proposed as an alternative to control resistant pathogens. However, due to multifunctional properties of several AMP classes, until now …
J Koehbach - Frontiers in Chemistry, 2017 - frontiersin.org
Insects make up the largest and most diverse group of organisms on earth with several million species to exist in total. Considering the sheer number of insect species and the vast …
S Zhu, B Gao, PJ Harvey… - Proceedings of the …, 2012 - National Acad Sciences
Fungi are a newly emerging source of peptide antibiotics with therapeutic potential. Here, we report 17 new fungal defensin-like peptide (fDLP) genes and the detailed …
S Zhu, S Peigneur, B Gao, Y Umetsu… - … biology and evolution, 2014 - academic.oup.com
Scorpion K+ channel toxins and insect defensins share a conserved three-dimensional structure and related biological activities (defense against competitors or invasive microbes …
C Tian, B Gao, Q Fang, G Ye, S Zhu - BMC genomics, 2010 - Springer
Abstract Background Antimicrobial peptides (AMPs) are an essential component of innate immunity which can rapidly respond to diverse microbial pathogens. Insects, as a rich …
B Gao, P Li, S Zhu - Journal of Medicinal Chemistry, 2024 - ACS Publications
Insect defensins are a large family of antimicrobial peptides primarily active against Gram- positive bacteria. Here, we explore their hidden anti-Gram-negative bacterial potential via a …
W Lee, DG Lee - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2015 - Elsevier
Abstract Bac8c (RIWVIWRR-NH 2) is an analogue peptide derived through complete substitution analysis of the linear bovine host defense peptide variant Bac2A. In the present …