Drug delivery systems designed to overcome antimicrobial resistance

TN Pham, P Loupias… - Medicinal research …, 2019 - Wiley Online Library
Antimicrobial resistance has emerged as a huge challenge to the effective treatment of
infectious diseases. Aside from a modest number of novel anti‐infective agents, very few …

Computational tools for exploring sequence databases as a resource for antimicrobial peptides

WF Porto, AS Pires, OL Franco - Biotechnology advances, 2017 - Elsevier
Data mining has been recognized by many researchers as a hot topic in different areas. In
the post-genomic era, the growing number of sequences deposited in databases has been …

[HTML][HTML] Cysteine-stabilized αβ defensins: from a common fold to antibacterial activity

R de Oliveira Dias, OL Franco - Peptides, 2015 - Elsevier
Antimicrobial peptides (AMPs) seem to be promising alternatives to common antibiotics,
which are facing increasing bacterial resistance. Among them are the cysteine-stabilized αβ …

CS-AMPPred: an updated SVM model for antimicrobial activity prediction in cysteine-stabilized peptides

WF Porto, ÁS Pires, OL Franco - PLoS One, 2012 - journals.plos.org
The antimicrobial peptides (AMP) have been proposed as an alternative to control resistant
pathogens. However, due to multifunctional properties of several AMP classes, until now …

Structure-activity relationships of insect defensins

J Koehbach - Frontiers in Chemistry, 2017 - frontiersin.org
Insects make up the largest and most diverse group of organisms on earth with several
million species to exist in total. Considering the sheer number of insect species and the vast …

Dermatophytic defensin with antiinfective potential

S Zhu, B Gao, PJ Harvey… - Proceedings of the …, 2012 - National Acad Sciences
Fungi are a newly emerging source of peptide antibiotics with therapeutic potential. Here,
we report 17 new fungal defensin-like peptide (fDLP) genes and the detailed …

Experimental conversion of a defensin into a neurotoxin: implications for origin of toxic function

S Zhu, S Peigneur, B Gao, Y Umetsu… - … biology and evolution, 2014 - academic.oup.com
Scorpion K+ channel toxins and insect defensins share a conserved three-dimensional
structure and related biological activities (defense against competitors or invasive microbes …

Antimicrobial peptide-like genes in Nasonia vitripennis: a genomic perspective

C Tian, B Gao, Q Fang, G Ye, S Zhu - BMC genomics, 2010 - Springer
Abstract Background Antimicrobial peptides (AMPs) are an essential component of innate
immunity which can rapidly respond to diverse microbial pathogens. Insects, as a rich …

Single deletion unmasks hidden anti-gram-negative bacterial activity of an insect defensin-derived peptide

B Gao, P Li, S Zhu - Journal of Medicinal Chemistry, 2024 - ACS Publications
Insect defensins are a large family of antimicrobial peptides primarily active against Gram-
positive bacteria. Here, we explore their hidden anti-Gram-negative bacterial potential via a …

[HTML][HTML] Fungicidal mechanisms of the antimicrobial peptide Bac8c

W Lee, DG Lee - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2015 - Elsevier
Abstract Bac8c (RIWVIWRR-NH 2) is an analogue peptide derived through complete
substitution analysis of the linear bovine host defense peptide variant Bac2A. In the present …