Neuroinflammation and Its Impact on the Pathogenesis of COVID-19

MM Almutairi, F Sivandzade, TH Albekairi… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical manifestations of COVID-19 …

SARS-CoV-2 involvement in central nervous system tissue damage

MA Haidar, Z Shakkour, MA Reslan… - Neural Regeneration …, 2022 - journals.lww.com
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread
globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the …

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

MR Garvin, C Alvarez, JI Miller, ET Prates, AM Walker… - elife, 2020 - elifesciences.org
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …

Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond

A Agostoni, E Aygören-Pürsün, KE Binkley… - Journal of Allergy and …, 2004 - Elsevier
Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute
attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to …

Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility

N Azinheira Nobrega Cruz, D Stoll, DE Casarini… - Clinical …, 2021 - portlandpress.com
In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory
syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence …

Identification of Conformational Variants for Bradykinin Biomarker Peptides from a Biofluid Using a Nanopore and Machine Learning

SJ Greive, L Bacri, B Cressiot, J Pelta - ACS nano, 2023 - ACS Publications
There is a current need to develop methods for the sensitive detection of peptide biomarkers
in complex mixtures of molecules, such as biofluids, to enable early disease detection …

Impaired breakdown of bradykinin and its metabolites as a possible cause for pulmonary edema in COVID-19 infection

S de Maat, Q de Mast, AHJ Danser… - … in thrombosis and …, 2020 - thieme-connect.com
A growing body of clinical evidence shows that vascular leakage leads to pulmonary edema
in coronavirus disease 2019 (COVID-19) patients. Coronaviruses including severe acute …

Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors

A Adam, M Cugno, G Molinaro, M Perez, Y Lepage… - The Lancet, 2002 - thelancet.com
Angio-oedema is a rare but potentially life threatening side-effect of angiotensin-converting-
enzyme (ACE) inhibitor treatment. Identification of individuals at risk of this adverse effect is …

Angiotensin-converting enzyme inhibitor-associated angioedema

JB Byrd, A Adam, NJ Brown - … and Allergy Clinics, 2006 - immunology.theclinics.com
Angiotensin-converting enzyme (ACE, kininase II) inhibitors reduce mortality in patients who
have hypertension, congestive heart failure, and diabetic nephropathy and in patients who …

Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor–associated angioedema

JB Byrd, K Touzin, S Sile, JV Gainer, C Yu… - …, 2008 - Am Heart Assoc
Angioedema is a potentially life-threatening adverse effect of angiotensin-converting
enzyme inhibitors. Bradykinin and substance P, substrates of angiotensin-converting …