Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment
that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS …

Two decades ago successful transfection of antigen presenting cells (APC) in vivo was
demonstrated which resulted in the induction of primary adaptive immune responses. Due to …

Highlights•KALA-LMWP-NLS chimeric peptide (KLN) was designed and expressed in E. coli
Bl21.•KLN/pDNA/Aptamer nanoparticles were synthesized using electrostatic self …

Simple Summary Gene therapy is one of the most promising approaches to treating various
inherited and acquired diseases by delivering genetic constructs into the cells and tissues of …

Nucleic acid nanoparticles are playing an increasingly important role in biomolecular
diagnostics and therapeutics as well as a variety of other areas. The unique attributes of self …

Stroke is the second leading cause of death globally and represents a major cause of
devastating long-term disability. Despite sustained efforts to develop clinically effective …

Concerns associated with nanocarriers' therapeutic efficacy and side effects have led to the
development of strategies to advance them into targeted and responsive delivery systems …

The design of non-viral vectors that efficiently deliver genetic materials into cells, in
particular to the nucleus, remains a major challenge in gene therapy and vaccine …

The effective delivery of nucleic acid therapeutics into tumor cells is of great importance in
terms of cancer gene therapy. Successful application of siRNAs is restricted by the …

In order to enhance the sensitivity of drug-resistant ovarian cancer cells to cisplatin (DDP), a
co-delivery system was designed for simultaneous delivery of curcumin (CUR) and p53 …