The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

The BUB3 protein plays a key role in the activation of the spindle assembly checkpoint
(SAC), a ubiquitous surveillance mechanism that ensures the fidelity of chromosome …

Accurate chromosome segregation during cell division requires amphitelic chromosome
attachment to the spindle apparatus. It is ensured by the combined activity of the spindle …

During mitosis, unattached kinetochores in a dividing cell signal to the spindle assembly
checkpoint (SAC) to delay anaphase onset and prevent chromosome missegregation. 1, 2 …

The spindle checkpoint monitors kinetochore-microtubule interactions and generates a" wait
anaphase" delay when any defects are apparent [1–3]. This provides time for cells to correct …

The cell cycle is the essential biological process where one cell replicates its genome and
segregates the resulting two copies into the daughter cells during mitosis. Several aspects of …

During mitosis, the Bub1–Bub3 complex concentrates at kinetochores, the microtubule-
coupling interfaces on chromosomes, where it contributes to spindle checkpoint activation …

The kinetochore drives chromosome segregation at cell division. It acts as a physical link
between chromosomes and dynamic microtubules, and as a signaling hub detecting and …