Overcoming and preventing cancer therapy resistance is the most pressing challenge in
modern breast cancer management. Consequently, most modern breast cancer research is …

Background & Aims Acute liver failure (ALF) is a life-threatening disease characterised by
high-grade inflammation and immunoparesis, which is associated with a high incidence of …

Individuals suffering from diverse neuropsychiatric and neurodegenerative disorders often
have comparable symptoms, which may underline the implication of shared hereditary …

Lysophosphatidic acid receptor 1 (LPAR1) antagonists show promise as potentially novel
antifibrotic treatments. In a human LPAR1 β-arrestin recruitment-based high-throughput …

Piperidine 3 is a potent and selective lysophosphatidic acid receptor subtype 1 receptor
(LPAR1) antagonist that has shown efficacy in a skin vascular leakage target engagement …

Lysophosphatidic acid receptors (LPARs) are six G-protein-coupled receptors that mediate
LPA signaling to promote tumorigenesis and therapy resistance in many cancer subtypes …

The developmental process of central nervous system (CNS) myelin sheath formation is
characterized by well‐coordinated cellular activities ultimately ensuring rapid and …

Functional loss of the motor protein myosin Vb (MYO5B) induces various defects in intestinal
epithelial function and causes a congenital diarrheal disorder, namely, microvillus inclusion …

Metastasis is responsible for about 90% of cancer deaths. Anti‐metastatic drugs, termed as
migrastatics, offer a distinctive therapeutic approach to address cancer migration and …

The unmatched chemo-, regio-, and stereoselectivity of enzymes renders them powerful
catalysts in the synthesis of chiral active pharmaceutical ingredients (APIs). Inspired by the …