Sensory effects of nicotine and tobacco

E Carstens, MI Carstens - Nicotine and Tobacco Research, 2022 - academic.oup.com
Introduction Ingestion of nicotine by smoking, vaping, or other means elicits various effects
including reward, antinociception, and aversion due to irritation, bitter taste, and unpleasant …

Flavor science in the context of research on electronic cigarettes

JE Hayes, AN Baker - Frontiers in Neuroscience, 2022 - frontiersin.org
Thousands start smoking or vaping daily, despite long-standing efforts by public health
authorities to curb initiation and use of nicotine containing products. Over the last 15 years …

Effect of chronic vapor nicotine exposure on affective and cognitive behavior in male mice

LB Murdaugh, C Miliano, I Chen, CL Faunce… - Scientific Reports, 2024 - nature.com
Nicotine use is a leading cause of preventable deaths worldwide, and most of those who
attempt to quit will relapse. While electronic cigarettes and other electronic nicotine delivery …

Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism

L Fan, S Balakrishna, SV Jabba, PE Bonner… - Tobacco …, 2016 - tobaccocontrol.bmj.com
Background Nicotine is a major oral irritant in smokeless tobacco products and has an
aversive taste. Mentholated smokeless tobacco products are highly popular, suggesting that …

[HTML][HTML] Potential risks of nicotine on the germination, growth, and nutritional properties of broad bean

YD Cheng, YX Bai, M Jia, Y Chen, D Wang… - Ecotoxicology and …, 2021 - Elsevier
This study evaluated the allelopathy, uptake and accumulation, and potential agricultural
and food safety risks of nicotine in broad bean (Vicia faba L.) during seed germination and …

Flavor additives facilitate oral self-administration of nicotine solution in mice

S Tannous, F Darlot, M Cador, S Caille - Psychopharmacology, 2021 - Springer
Rationale Tobacco products are very addictive, partly because they contain nicotine which is
reinforcing, but also because they include appealing aromas and tastes. Flavor additives are …

Spilanthol enhances sensitivity to sodium in mouse taste bud cells

J Xu, BC Lewandowski, T Miyazawa, Y Shoji… - Chemical …, 2019 - academic.oup.com
Overconsumption of NaCl has been linked to increased hypertension-related morbidity.
Compounds that can enhance NaCl responses in taste cells could help reduce human NaCl …

Heightened olfactory dysfunction and oral irritation among chronic smokers and heightened propylthiouracil (PROP) bitterness among menthol smokers

VB Duffy, SG Glennon, BA Larsen, S Rawal… - Physiology & …, 2019 - Elsevier
Chronic cigarette smoking may influence chemosensory function, which in turn, may affect
cigarette usage. Because menthol in cigarettes can attenuate nicotine bitterness, choice of …

From cell to beak: in-vitro and in-vivo characterization of chicken bitter taste thresholds

S Cheled-Shoval, M Behrens, A Korb, A Di Pizio… - Molecules, 2017 - mdpi.com
Bitter taste elicits an aversive reaction, and is believed to protect against consuming
poisons. Bitter molecules are detected by the Tas2r family of G-protein-coupled receptors …

Voluntary nicotine consumption and reward in a subset of diversity outbred founder strains

Y Rahman, B Buzzi, W Rogers… - Journal of …, 2024 - journals.sagepub.com
Background: Nicotine is largely responsible for the initiation and maintenance of tobacco
dependence and contributes to a global health problem. Aims: This study characterizes …