Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy
The last 15 years have seen a paradigm shift in our understanding of protein biochemistry,
with the realization that an unexpectedly high fraction of the human genome codes for …
with the realization that an unexpectedly high fraction of the human genome codes for …
Dynamic protein interaction networks and new structural paradigms in signaling
Understanding signaling and other complex biological processes requires elucidating the
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …
Global structure of the intrinsically disordered protein tau emerges from its local structure
The paradigmatic disordered protein tau plays an important role in neuronal function and
neurodegenerative diseases. To disentangle the factors controlling the balance between …
neurodegenerative diseases. To disentangle the factors controlling the balance between …
Flexible-meccano: a tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables
Abstract Motivation: Intrinsically disordered proteins (IDPs) represent a significant fraction of
the human proteome. The classical structure function paradigm that has successfully …
the human proteome. The classical structure function paradigm that has successfully …
NMR characterization of long-range order in intrinsically disordered proteins
Intrinsically disordered proteins (IDPs) are predicted to represent a significant fraction of the
human genome, and the development of meaningful molecular descriptions of these …
human genome, and the development of meaningful molecular descriptions of these …
Describing intrinsically disordered proteins at atomic resolution by NMR
There is growing interest in the development of physical methods to study the
conformational behaviour and biological activity of intrinsically disordered proteins (IDPs). In …
conformational behaviour and biological activity of intrinsically disordered proteins (IDPs). In …
Biophysical characterization of intrinsically disordered proteins
D Eliezer - Current opinion in structural biology, 2009 - Elsevier
The challenges associated with the structural characterization of disordered proteins have
resulted in the application of a host of biophysical methods to such systems. NMR …
resulted in the application of a host of biophysical methods to such systems. NMR …
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins
M Varadi, S Kosol, P Lebrun, E Valentini… - Nucleic acids …, 2014 - academic.oup.com
The goal of pE-DB (http://pedb. vib. be) is to serve as an openly accessible database for the
deposition of structural ensembles of intrinsically disordered proteins (IDPs) and of …
deposition of structural ensembles of intrinsically disordered proteins (IDPs) and of …
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase
Intrinsically disordered proteins can form highly dynamic complexes with partner proteins.
One such dynamic complex involves the intrinsically disordered Sic1 with its partner Cdc4 in …
One such dynamic complex involves the intrinsically disordered Sic1 with its partner Cdc4 in …
Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering
The development of molecular descriptions of intrinsically disordered proteins (IDPs) is
essential for elucidating conformational transitions that characterize common …
essential for elucidating conformational transitions that characterize common …