Autophagy and Alzheimer's disease

Q Li, Y Liu, M Sun - Cellular and molecular neurobiology, 2017 - Springer
Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in
mammalian cells and is responsible for protein homeostasis and neuronal health. Several …

Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions

A Dey, R Bhattacharya, A Mukherjee… - Biotechnology advances, 2017 - Elsevier
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease
associated with memory and cognition impairment ultimately leading to death. It is the …

Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease

NK Jha, SK Jha, R Kar, P Nand, K Swati… - Journal of …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with
worldwide prevalence. Its clinical manifestation involves the presence of extracellular …

Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer's disease

A Xuan, D Long, J Li, W Ji, M Zhang, L Hong… - Journal of …, 2012 - Springer
Background Endogenously produced hydrogen sulfide (H 2 S) may have multiple functions
in brain. An increasing number of studies have demonstrated its anti-inflammatory effects. In …

Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions

X Li, XY Ma, YF Feng, ZS Ma, J Wang, TC Ma, W Qi… - Biomaterials, 2015 - Elsevier
Chitosan coated porous titanium alloy implant (CTI) is demonstrated a promising approach
to improve osseointegration capacity of pure porous titanium alloy implant (TI). Since …

Reactive oxygen species, redox signaling and neuroinflammation in Alzheimer's disease: the NF-κB connection

U Kaur, P Banerjee, A Bir, M Sinha… - Current topics in …, 2015 - ingentaconnect.com
Oxidative stress and inflammatory response are important elements of Alzheimer's disease
(AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with …

Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-β1–42-induced rat model of Alzheimer's disease

S Jia, Z Lu, Z Gao, J An, X Wu, X Li, X Dai… - International journal of …, 2016 - Elsevier
Aim The objective of the present study was two-fold:(i) to evaluate the modulating effects of
chitosan oligosaccharides (COS) on cognitive deficits and (ii) to explore their underlying …

Nicotinamide ameliorates amyloid beta-induced oxidative stress-mediated neuroinflammation and neurodegeneration in adult mouse brain

IU Rehman, R Ahmad, I Khan, HJ Lee, J Park, R Ullah… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is the most predominant age-related neurodegenerative disease,
pathologically characterized by the accumulation of aggregates of amyloid beta Aβ1–42 and …

Carvacrol protects neuroblastoma SH-SY5Y cells against Fe2+-induced apoptosis by suppressing activation of MAPK/JNK-NF-κB signaling pathway

Z Cui, Z Xie, B Wang, Z Zhong, X Chen, Y Sun… - Acta Pharmacologica …, 2015 - nature.com
Aim: Carvacrol (2-methyl-5-isopropylphenol), a phenolic monoterpene in the essential oils of
the genera Origanum and Thymus, has been shown to exert a variety of therapeutic effects …

Tropisetron attenuates amyloid‐beta‐induced inflammatory and apoptotic responses in rats

R Rahimian, G Fakhfouri… - European journal of …, 2013 - Wiley Online Library
Background Alzheimer's disease (AD) is a neurodegenerative disorder featured by
deposition of beta‐amyloid (Aβ) plaques in the hippocampus and associated cortices and …