Background Theories of the intergenerational transmission of depression emphasize
alterations in emotion processing among offspring of depressed mothers as a key risk …

Depression is a highly prevalent and debilitating mental disorder that often begins in
adolescence. However, it remains unclear whether adults and adolescents with depression …

Although the intergenerational transmission of risk for depression is well documented, the
mechanisms and moderators involved in this transmission of risk from depressed parents to …

Structural and functional brain alterations are found in adults with depression. It is not known
whether these changes are a result of illness or exist prior to disorder onset. Asymptomatic …

Background A growing body of research has demonstrated that adolescent offspring of
depressed parents show diminished responding in the ventral striatum to reward. More …

Pediatric irritability is the most robust indicator of transdiagnostic psychopathology risk. It is
associated with altered neural reward processing, including neural networks related to …

Objective Although chronic irritability in childhood is prevalent, impairing, and predictive of
later maladjustment, its pathophysiology is largely unknown. Deficits in reward processing …

Irritability is impairing and prevalent across pediatric psychiatric disorders and typical
development, yet its neural mechanisms are largely unknown. This study evaluated the …

Objectives Early life stress likely contributes to dysfunction in neural reward processing
systems. However, studies to date have focused almost exclusively on adolescents and …

Guided by developmental psychopathology and dual-risk frameworks, the present study
examined the interplay between childhood maltreatment and maternal major depression …