Sequential design methods for binary response variables exist for determination of the
concentration or dose associated with the 50% point along the dose-response curve; the up …

The up-and-down procedure (UDP), fixed-dose procedure (FDP) and conventional LD50
tests were compared to determine their consistency in chemical hazard classification for …

Selective laser melting fabricated materials regularly exhibit excellent static strength, thanks
to the very high thermal gradient that characterizes the process; however, their performance …

During the past decade a number of variations in the simple up‐down procedure have been
used in psychoacoustic testing. A broad class of these methods is described with due …

This textbook for a basic statistics course assumes, mathematics to only algebraic addition,
subtraction, and multiplication. Text discussion, examples, and problems utilize material …

A modified up-and-down method for sensitivity testing (all-or-none assays) is presented with
maximum likelihood estimates of LD50 tabulated for all sample sequences for nominal …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Weak lead stimulation can modify the human startle reflex It is proposed that, with the aid of
physiological measures taken in the interval between lead and startle stimuli, this paradigm …

We describe an adaptive dose escalation scheme for use in cancer phase I clinical trials.
The method is fully adaptive, makes use of all the information available at the time of each …

In recent years, increasing attention has been given to the statistical aspects of contingent
valuation (CV) survey design and data analysis. The main reason for the growing interest in …