Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The mammalian genome is depleted in CG dinucleotides, except at protected regions where
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …

Response rates to immunotherapy in solid tumors remain low due in part to the elevated
prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced …

PURPOSE Neuroblastoma is the most common extracranial solid tumor in childhood. We
previously showed that circulating cell-free DNA (cfDNA) and tumor biopsy derived 5 …

How neurons can maintain cellular identity over an entire life span remains largely
unknown. Here, we show that maintenance of identity in differentiated dopaminergic and …

Bivalent chromatin with active H3K4me3 and repressive H3K27me3 was initially identified in
embryonic stem cells (ESCs) to poise expression of developmental genes upon lineage …

Neurovývojová onemocnění (NDD) jsou onemocnění charakterizována abnormálním
vývojem centrálního nervového systému a mozku, zároveň mohou být spojena se …

Abstract ADNP encodes Activity-Dependent Neuroprotective Protein, whose de novo
heterozygous mutations cause Helsmoortel-Van der Aa Syndrome (HVDAS), a rare …

Living systems, from entire organisms down to the single cells constituting them aredynamic
entities that continuously adapt and respond to their local environment. Cellsachieve this …