New horizons in lung cancer management through ATR/CHK1 pathway modulation

R Thapa, O Afzal, AA Bhat, A Goyal… - Future medicinal …, 2023 - Taylor & Francis
Lung cancer is the leading cause of cancer-related deaths worldwide. Molecular profiling
has contributed to a new classification of lung cancer, driving advancements in research and …

[HTML][HTML] Optimizing CRISPR/Cas9 precision: Mitigating off-target effects for safe integration with photodynamic and stem cell therapies in cancer treatment

JPJ Merlin, H Abrahamse - Biomedicine & Pharmacotherapy, 2024 - Elsevier
CRISPR/Cas9 precision genome editing has revolutionized cancer treatment by introducing
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …

Role of antioxidant vitamins and other micronutrients on regulations of specific genes and signaling pathways in the prevention and treatment of cancer

OF Fagbohun, CR Gillies, KPJ Murphy… - International Journal of …, 2023 - mdpi.com
Cancer is an escalating global issue, with 19.3 million new cases and 9.9 million deaths in
2020. Therefore, effective approaches to prevent cancer are urgently required. Diet plays a …

Anthocyanin encapsulated nanoparticles as a pulmonary delivery system

M Amararathna, DW Hoskin… - … Medicine and Cellular …, 2022 - Wiley Online Library
Anthocyanins are known for their therapeutic efficacy for many human diseases, including
cancer. After ingestion, anthocyanins degrade due to oxidation and enzymatic breakdown …

Genistein and procyanidin B2 reduce carcinogen-induced reactive oxygen species and DNA damage through the activation of Nrf2/ARE cell signaling in Bronchial …

TL Suraweera, JPJ Merlin, G Dellaire, Z Xu… - International Journal of …, 2023 - mdpi.com
Cancer is one of the leading causes of death worldwide. Chemotherapy and radiation
therapy are currently providing the basis for cancer therapies, although both are associated …

[HTML][HTML] Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes

JPJ Merlin, A Crous, H Abrahamse - International journal of molecular …, 2024 - mdpi.com
Cancer treatment continues to be a substantial problem due to tumor complexities and
persistence, demanding novel therapeutic techniques. This review investigates the …

Nano‐phototherapy: Favorable prospects for cancer treatment

JPJ Merlin, A Crous… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Nanotechnology‐based phototherapies have drawn interest in the fight against cancer
because of its noninvasiveness, high flexibility, and precision in terms of cancer targeting …

Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications

SS Rajan, R Chandran… - International Journal of …, 2024 - Taylor & Francis
Hypocrellin-based photodynamic therapy (PDT) is developing as a viable cancer
therapeutic option, especially when enhanced by nanoconjugation. This review investigates …

Antidiabetic, Antiglycation, and Antioxidant Activities of Ethanolic Seed Extract of Passiflora edulis and Piceatannol In Vitro

FAR Dos Santos, JA Xavier, FC da Silva, JPJ Merlin… - Molecules, 2022 - mdpi.com
The objective of this work was to investigate the antidiabetic, antiglycation, and antioxidant
potentials of ethanolic extract of seeds of Brazilian Passiflora edulis fruits (PESE), a major by …

A dietary antioxidant formulation ameliorates DNA damage caused by γ-irradiation in normal human bronchial epithelial cells in vitro

JPJ Merlin, S Mathavarajah, G Dellaire, KPJ Murphy… - Antioxidants, 2022 - mdpi.com
Antioxidants can be used as radioprotectants to reduce DNA damage due to exposure to
radiation that could result in malignancies, including lung cancer. Mortality rates are …