Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Environmental endocrine-disrupting chemicals (EDCs), a type of exogenous organic
pollutants, are ubiquitous in natural aquatic environments. Therefor, this review focused on …

Microglia play a critical role in brain homeostasis and disease progression. In
neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD) …

The Y-maze can be used to assess short term memory in mice. Spontaneous alternation, a
measure of spatial working memory, can be assessed by allowing mice to explore all three …

The hippocampus plays a critical role in goal-directed navigation. Across different
environments, however, hippocampal maps are randomized, making it unclear how goal …

Aging involves a decline in neural function that contributes to cognitive impairment and
disease. However, the mechanisms underlying the transition from a young-and-healthy to …

Through the generation of humanized FUS mice expressing full-length human FUS, we
identify that when expressed at near endogenous murine FUS levels, both wild-type and …

It has been well documented that neurotrophins, including brain-derived neurotrophic factor
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …

Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins
(RBPs). We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo …

Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a
widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid …