Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic
producers are an integral part of the growing antibiotic resistance threat. The origins of …

The beta-lactam antibiotics have been serving mankind for over 70years. Despite this old
age, they continue to provide health to the world population by virtue of industrial production …

Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …

Background Some types of flavonoid intermediates seemed to be restricted to plants.
Naringenin is a typical plant metabolite, that has never been reported to be produced in …

The increase in availability of actinobacterial whole genome sequences has revealed huge
numbers of specialised metabolite biosynthetic gene clusters, encoding a range of bioactive …

Clavulanic acid (CA) is a potent β-lactamase inhibitor produced by Streptomyces
clavuligerus and has been successfully used in combination with β-lactam antibiotics (for …

Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak
antibacterial activity produced by Streptomyces clavuligerus (S. clavuligerus). CA is typically …

Background In addition to its outstanding cellulase production ability, Trichoderma reesei
produces a wide variety of valuable secondary metabolites, the production of which has not …

Streptomyces species produce an incredible array of high-value specialty chemicals and
medicinal therapeutics. A single species typically harbors~ 30 biosynthetic pathways, but …