Publisher Summary Calmodulin is the major intracellular, and intramembrane, Ca 2+
receptor. Its function is to detect free Ca 2+ and translate changes in Ca 2+ concentrations …

The dynamic nature of synaptic connections has presented morphologists with considerable
problems which, from a structural perspective, have frustrated the development of ideas on …

Objective Mounting evidence suggests that α‐synuclein, a major protein component of Lewy
bodies (LB), may be responsible for initiating and spreading the pathological process in …

Synapsin I (protein I) is a neuron-specific phosphoprotein, which is a substrate for cAMP-
dependent and Ca/calmodulin-dependent protein kinases. In two accompanying studies (De …

Postsynaptic densities (PSDs) have been isolated from cerebral cortex, midbrain,
cerebellum, and brain stem by the Triton X-100 method previously used in the isolation of …

Lewy bodies, the pathological hallmark of dementia with Lewy bodies (DLB), are large
juxtanuclear inclusions of aggregated α-synuclein. However, the small number of cortical …

To support the role of DISC1 in human psychiatric disorders, we identified and analyzed two
independently derived ENU-induced mutations in Exon 2 of mouse Disc1. Mice with …

To further elucidate the mechanism of organelle transport, we cloned a novel member of the
mouse kinesin superfamily, KIFlB. This N-terminal-type motor protein is expressed …

We have examined the cytoskeletal architecture and its relationship with synaptic vesicles in
synapses by quick-freeze deep-etch electron microscopy (QF. DE). The main cytoskeletal …

Synapsin I (formerly referred to as protein I) is the collective name for two almost identical
phosphoproteins, synapsin Ia and synapsin Ib (protein Ia and protein Ib), present in the …