Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Strategic Design of Luminescent Rhenium (I), Ruthenium (II), and Iridium (III) Complexes as Activity‐Based Probes for Bioimaging and Biosensing

LCC Lee, KKW Lo - Chemistry–An Asian Journal, 2022 - Wiley Online Library
The rapid development of responsive fluorescent probes has advanced optical imaging for
biological research and biomedical applications. Among different sensing strategies, activity …

Photoactive and luminescent transition metal complexes as anticancer agents: A guiding light in the search for new and improved cancer treatments

BS McGhie, JR Aldrich-Wright - Biomedicines, 2022 - mdpi.com
Cancer continues to be responsible for the deaths of more than 9 million people worldwide
each year. Current treatment options are diverse, but low success rates, particularly for those …

Bioorthogonal dissociative rhenium (i) photosensitisers for controlled immunogenic cell death induction

GX Xu, LCC Lee, PKK Leung, ECL Mak, J Shum… - Chemical …, 2023 - pubs.rsc.org
Photosensitisers for photoimmunotherapy with high spatiotemporal controllability are rare. In
this work, we designed rhenium (I) polypyridine complexes modified with a tetrazine unit via …

Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

LCC Lee, KKW Lo - Small Methods, 2024 - Wiley Online Library
Despite the advent of various medical interventions for cancer treatment, the disease
continues to pose a formidable global health challenge, necessitating the development of …

A new family of luminescent [Pt (pbt) 2 (C 6 F 5) L] n+ (n= 1, 0) complexes: synthesis, optical and cytotoxic studies

DG de Segura, N Giménez, D Rincón-Montón… - Dalton …, 2023 - pubs.rsc.org
Given the widely recognized bioactivity of 2-arylbenzothiazoles against tumor cells, we have
designed a new family of luminescent heteroleptic pentafluorophenyl-bis (2 …

Organometallic d6, d8 and d10 metal complexes for biosensing and imaging, cancer therapy and theranosis

YY Lam, NS Lee, SF Lee, CYS Chung - Journal of Organometallic …, 2024 - Elsevier
Organometallic d 6, d 8 and d 10 metal complexes are known for their interesting
photophysical and photochemical properties. This allows many of them to develop into …

Photophysics of transition metal complexes (2021–2022)

S La Cognata, D Vadivel, A Poggi, D Dondi… - 2023 - books.rsc.org
This Chapter summarizes the major advances in the photophysics of transition metal
complexes, achieved in 2021 and 2022, covering mainly d-block metal complexes. The …

Strategic design of photofunctional transition metal complexes for cancer diagnosis and therapy

LCC Lee, KKW Lo - Advances in Inorganic Chemistry, 2022 - Elsevier
Cancer is one of the most important public health problems and poses a serious threat to
human life. The development of innovative diagnostic and therapeutic agents for rapid …