Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

The serotonergic pathways originating in the dorsal and median raphe nuclei (DR and MnR,
respectively) are critically involved in cortical function. Serotonin (5-HT), acting on …

Introduction Taking microdoses (a mere fraction of normal doses) of psychedelic
substances, such as truffles, recently gained popularity, as it allegedly has multiple …

Serotonin (5-hydroxytryptamine, 5-HT), the “happy hormone,” has a phylogenetically ancient
role in neural transmission (Turlejski, 1996). Because the serotonergic system has a …

Morphological studies show that repeated restraint stress leads to selective atrophy in the
apical dendritic field of pyramidal cells in the medial prefrontal cortex (mPFC). However, the …

Evidence of a link between genetic variation of the serotonin transporter and depression and
anxiety prompted the generation of serotonin transporter knockout mice. Loss of serotonin …

Abstract Development passes through sensitive periods, during which plasticity allows for
genetic and environmental factors to exert indelible influence on the maturation of the …

Human studies have shown that a reduction of 5-HT transporter (SERT) increases the
vulnerability for anxiety and depression. Moreover, women are more vulnerable to develop …

Serotonin receptors of the 5-HT2A subtype are robustly expressed in the cerebral cortex
where they have been implicated in the pathophysiology and therapeutics of mental …

Layer V pyramidal neurons in the rat medial prefrontal cortex (PFC) were examined with
whole cell patch-clamp recording in acute slices from postnatal day 1 (P1) to P36. In the first …