Cancer is a destructive disease that causes high levels of morbidity and mortality.
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …

Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat
various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical …

Acute kidney injury (AKI) is a syndrome of abrupt loss of renal functions. The underlying
pathological mechanisms of AKI remain largely unknown. BCL2-interacting protein 3 …

Autophagy is a highly conserved process that maintains cellular homeostasis during
evolution. Autophagy can occur in the form of macroautophagy, microautophagy or …

BNIP3 and NIX are proteins related to the BH3-only family, which induce both cell death and
autophagy. Consistent with their ability to induce cell death, BNIP3 and NIX are implicated in …

Excess generation of reactive oxygen species (ROS) and cytosolic calcium accumulation
play major roles in the initiation of programmed cell death during acute myocardial …

Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that
cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer …

Introduction A basal level of mitophagy is essential in mitochondrial quality control in
physiological conditions, while excessive mitophagy contributes to cell death in a number of …

Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-
recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular …