Biomaterial-based antimicrobial therapies for the treatment of bacterial infections

PP Kalelkar, M Riddick, AJ García - Nature Reviews Materials, 2022 - nature.com
The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Y Jiang, Y Chen, Z Song, Z Tan, J Cheng - Advanced Drug Delivery …, 2021 - Elsevier
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …

Addressing MRSA infection and antibacterial resistance with peptoid polymers

J Xie, M Zhou, Y Qian, Z Cong, S Chen… - Nature …, 2021 - nature.com
Abstract Methicillin-Resistant Staphylococcus aureus (MRSA) induced infection calls for
antibacterial agents that are not prone to antimicrobial resistance. We prepare protease …

Bioactive synthetic polymers

K Jung, N Corrigan, EHH Wong, C Boyer - Advanced Materials, 2022 - Wiley Online Library
Synthetic polymers are omnipresent in society as textiles and packaging materials, in
construction and medicine, among many other important applications. Alternatively, natural …

Secondary amine pendant β-peptide polymers displaying potent antibacterial activity and promising therapeutic potential in treating MRSA-induced wound infections …

Y Qian, S Deng, Z Cong, H Zhang, Z Lu… - Journal of the …, 2022 - ACS Publications
Interest in developing antibacterial polymers as synthetic mimics of host defense peptides
(HPDs) has accelerated in recent years to combat antibiotic-resistant bacterial infections …

A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset

W Chin, G Zhong, Q Pu, C Yang, W Lou… - Nature …, 2018 - nature.com
Polymyxins remain the last line treatment for multidrug-resistant (MDR) infections. As
polymyxins resistance emerges, there is an urgent need to develop effective antimicrobial …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies

Z Si, W Zheng, D Prananty, J Li, CH Koh, ET Kang… - Chemical …, 2022 - pubs.rsc.org
The growing prevalence of antimicrobial drug resistance in pathogenic bacteria is a critical
threat to global health. Conventional antibiotics still play a crucial role in treating bacterial …

Antimicrobial polymeric materials with quaternary ammonium and phosphonium salts

Y Xue, H Xiao, Y Zhang - International journal of molecular sciences, 2015 - mdpi.com
Polymeric materials containing quaternary ammonium and/or phosphonium salts have been
extensively studied and applied to a variety of antimicrobial-relevant areas. With various …

Green fabrication of amphiphilic quaternized β‐chitin derivatives with excellent biocompatibility and antibacterial activities for wound healing

H Xu, Z Fang, W Tian, Y Wang, Q Ye… - Advanced …, 2018 - Wiley Online Library
Bacterial infection has always been a great threat to public health, and new antimicrobials to
combat it are urgently needed. Here, a series of quaternized β‐chitin derivatives is prepared …