Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad
prospects for human therapeutic model development and livestock breeding. Despite …

Pluripotent stem cells (PSCs) harbor the capacity of unlimited self-renewal and multilineage
differentiation potential, which are crucial for basic research and biomedical science …

Pigs (Sus scrofa) are widely acknowledged as an important large mammalian animal model
due to their similarity to human physiology, genetics, and immunology. Leveraging the full …

Genome integration‐free pig induced pluripotent stem cells (iPSCs) bring tremendous value
in pre‐clinical testing of regenerative medicine, as well as conservation and exploitation of …

Stem cells intrinsically express a subset of genes which are normally associated with
interferon stimulation and the innate immune response. However, the expression of these …

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) requires activation
of the pluripotency network and resetting of the epigenome by erasing the epigenetic …

Over the last 25 years, cloned animals have been produced by transferring somatic cell
nuclei into enucleated oocytes (SCNT) in more than 20 mammalian species. Among …

The incomplete silencing of exogenous transcription factors (TFs) and the lack of
endogenous counterpart activation hampers the application of porcine induced pluripotent …

Myocardial infarction is the main driver of heart failure due to ischemia and subsequent cell
death, and cell-based strategies have emerged as promising therapeutic methods to replace …

Stem cells intrinsically express a subset of genes which are normally associated with
interferon stimulation, and thus the innate immunity response. Expression of these interferon …