Biomarker-driven molecular imaging probes in radiotherapy

H Li, Q Gong, K Luo - Theranostics, 2024 - pmc.ncbi.nlm.nih.gov
Background: Biomarker-driven molecular imaging has emerged as an integral part of cancer
precision radiotherapy. The use of molecular imaging probes, including nanoprobes, have …

Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma

G Li, D Wang, Y Zhai, C Pan, J Zhang, C Wang… - Cell Metabolism, 2024 - cell.com
Patients with high ALDH1A3-expressing glioblastoma (ALDH1A3 hi GBM) show limited
benefit from postoperative chemoradiotherapy. Understanding the mechanisms underlying …

[HTML][HTML] The Role of the Microbiome and of Radiotherapy-Derived Metabolites in Breast Cancer

L Herrera-Quintana, H Vázquez-Lorente, RCMC Silva… - Cancers, 2024 - mdpi.com
The gut microbiome has emerged as a crucial player in modulating cancer therapies,
including radiotherapy. In the case of breast cancer, the interplay between the microbiome …

Detection and characterization of colorectal cancer by autofluorescence lifetime imaging on surgical specimens

AI Herrando, LM Fernandez, J Azevedo, P Vieira… - Scientific Reports, 2024 - nature.com
Colorectal cancer (CRC) ranks among the most prevalent malignancies worldwide, driving a
quest for comprehensive characterization methods. We report a characterization of the ex …

Sensing Biomolecules Associated with Cells' Radiosusceptibility by Advanced Micro-and Nanospectroscopy Techniques

K Chrabąszcz, K Pogoda, K Cieżak, A Panek… - ACS …, 2024 - ACS Publications
Radiotherapy is one of the most common approaches for cancer treatment, especially in the
case of peripheral nervous system tumors. As it requires exposure to high doses of ionizing …

[HTML][HTML] Exploring the Metabolic Impact of FLASH Radiotherapy

F Geirnaert, L Kerkhove, P Montay-Gruel, T Gevaert… - Cancers, 2025 - mdpi.com
Abstract FLASH radiotherapy (FLASH RT) is an innovative modality in cancer treatment that
delivers ultrahigh dose rates (UHDRs), distinguishing it from conventional radiotherapy …

[HTML][HTML] Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer

S Benavente - Cancer Drug Resistance, 2023 - ncbi.nlm.nih.gov
Despite intensive efforts and refined techniques, overall survival in HPV-negative head and
neck cancer remains poor. Robust immune priming is required to elicit a strong and durable …

Deconvolution of cell-type-associated markers predictive of response to neoadjuvant radiotherapy

M Zhu, X Sun, J Fang, X Li - Computational Biology and Chemistry, 2024 - Elsevier
Tumor microenvironent contains prognostic molecular markers and therapeutic targets from
different cellular sources, which are still not fully revealed in the resistance and recurrence …

Glioblastomas: Hijacking Metabolism to Build a Flexible Shield for Therapy Resistance

J Bailleul, E Vlashi - Antioxidants & Redox Signaling, 2023 - liebertpub.com
Significance: Glioblastomas (GBMs) are among the most lethal tumors despite the almost
exclusive localization to the brain. This is largely due to therapeutic resistance. Radiation …

High resolution optical spectroscopy for the evaluation of cannabidiol efficiency as a radiation therapy support of peripheral nervous system tumors

K Chrabąszcz, K Pogoda, K Cieżak, A Panek… - bioRxiv, 2023 - biorxiv.org
An increasing number of scientific papers discuss the promising therapeutic potential of
cannabidiol (CBD) not only for the treatment of cancer, but also for asthma and …