Dental agenesis: genetic and clinical perspectives

PJ De Coster, LA Marks, LC Martens… - Journal of Oral …, 2009 - Wiley Online Library
Dental agenesis is the most common developmental anomaly in humans and is frequently
associated with several other oral abnormalities. Whereas the incidence of missing teeth …

Developmental disorders of the dentition: an update

OD Klein, S Oberoi, A Huysseune… - American Journal of …, 2013 - Wiley Online Library
Dental anomalies are common congenital malformations that can occur either as isolated
findings or as part of a syndrome. This review focuses on genetic causes of abnormal tooth …

MSX1, PAX9, and TGFA Contribute to Tooth Agenesis in Humans

AR Vieira, R Meira, A Modesto… - Journal of dental …, 2004 - journals.sagepub.com
In this study, we sought to determine the association between tooth agenesis and DNA
sequence variation in the genes MSX1 and PAX9 in an ethnically diverse human …

Familial human hypodontia–is it all in the genes?

MT Cobourne - British dental journal, 2007 - nature.com
The congenital absence of teeth is one of the commonest developmental abnormalities seen
in human populations. Familial hypodontia or oligodontia represents an absence of varying …

Genes affecting tooth morphogenesis

H Kapadia, G Mues, R D'souza - Orthodontics & craniofacial …, 2007 - Wiley Online Library
Structured Abstract Author–Hitesh Kapadia, Gabriele Mues, Rena D'Souza The
development of dentition is a fascinating process that encompasses a complex series of …

Novel MSX1 Frameshift Causes Autosomal-dominant Oligodontia

JW Kim, JP Simmer, BPJ Lin… - Journal of dental …, 2006 - journals.sagepub.com
Can kindreds with tooth agenesis caused by MSX1 or PAX9 mutations be distinguished by
their phenotypes? We have identified an MSX1 second bicuspids and mandibular central …

Diseases of the tooth: the genetic and molecular basis of inherited anomalies affecting the dentition

MT Cobourne, PT Sharpe - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
In humans, inherited variation in the number, size, and shape of teeth within the dentitions
are relatively common, while rarer defects of hard tissue formation, including amelogenesis …

[HTML][HTML] Prevalence and genetic basis of tooth agenesis

T Shimizu, T Maeda - Japanese Dental Science Review, 2009 - Elsevier
Tooth agenesis or hypodontia is one of the most common anomalies of the human dentition,
characterized by the developmental absence of one or more teeth. Many studies have …

Genetic basis of non-syndromic anomalies of human tooth number

G Galluccio, M Castellano, C La Monaca - Archives of Oral Biology, 2012 - Elsevier
Teeth organogenesis develops through a well-ordered series of inductive events involving
genes and BMP, FGF, SHH and WNT represent the main signalling pathways that regulate …

Novel Mutation of the Initiation Codon of PAX9 Causes Oligodontia

ML Klein, P Nieminen, L Lammi… - Journal of dental …, 2005 - journals.sagepub.com
Tooth development is under strict genetic control. Oligodontia is defined as the congenital
absence of 6 or more permanent teeth, excluding the third molar. The occurrence of non …