Lessons from the host defences of bats, a unique viral reservoir

AT Irving, M Ahn, G Goh, DE Anderson, LF Wang - Nature, 2021 - nature.com
There have been several major outbreaks of emerging viral diseases, including Hendra,
Nipah, Marburg and Ebola virus diseases, severe acute respiratory syndrome (SARS) and …

Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases

M Ahn, VCW Chen, P Rozario, WL Ng, P San Kong… - Cell, 2023 - cell.com
Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …

Exploring the role of innate lymphocytes in the immune system of bats and virus-host interactions

WR Sia, Y Zheng, F Han, S Chen, S Ma, LF Wang… - Viruses, 2022 - mdpi.com
Bats are reservoirs of a large number of viruses of global public health significance,
including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS …

Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea

AM Gamage, WOY Chan, F Zhu, YT Lim, S Long… - Immunity, 2022 - cell.com
Bats are reservoir hosts of many zoonotic viruses with pandemic potential. We utilized single-
cell transcriptome sequencing (scRNA-seq) to analyze the immune response in bat lungs …

Landscape and age dynamics of immune cells in the Egyptian rousette bat

V Friedrichs, C Toussaint, A Schäfer, M Rissmann… - Cell Reports, 2022 - cell.com
Bats harbor high-impact zoonotic viruses often in the absence of disease manifestation. This
restriction and disease tolerance possibly rely on specific immunological features. In-depth …

Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level

S Kessler, B Burke, G Andrieux, J Schinköthe… - Nature …, 2024 - nature.com
Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human
relevance. These infections are typically mild in bats, suggesting unique features of their …

Thymoquinone effect on monocyte-derived macrophages, cell-surface molecule expression, and phagocytosis

NA Alkhattabi, SA Hussein, NI Tarbiah, RY Alzahri… - Nutrients, 2022 - mdpi.com
Macrophages are one of the most important cells in the immune system. They act as links
between innate and adaptive immunities. In this study, the aim was to examine …

The translational potential of studying bat immunity

K Baid, AT Irving, N Jouvenet, A Banerjee - Trends in Immunology, 2024 - cell.com
Molecular studies in bats have led to the discovery of antiviral adaptations that may explain
how some bat species have evolved enhanced immune tolerance towards viruses …

[HTML][HTML] Immunological features of bats: resistance and tolerance to emerging viruses

WL Demian, O Cormier, K Mossman - Trends in Immunology, 2024 - cell.com
Bats are among the most diverse mammalian species, representing over 20% of mammalian
diversity. The past two decades have witnessed a disproportionate spillover of viruses from …

MR1-restricted T cells with MAIT-like characteristics are functionally conserved in the pteropid bat pteropus alecto

E Leeansyah, YY Hey, WR Sia, JHJ Ng, MY Gulam… - Iscience, 2020 - cell.com
Bats are reservoirs for a large number of viruses which have potential to cause major human
disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic …