Structural and mechanistic investigations on CC bond forming α-oxoamine synthase allowing L-glutamate as substrate
DK Zhang, KY Song, YQ Yan, JT Zheng, J Xu… - International Journal of …, 2024 - Elsevier
Abstract Carbon‑carbon (C—C) bonds serve as the fundamental structural backbone of
organic molecules. As a critical Csingle bondC bond forming enzyme, α-oxoamine synthase …
organic molecules. As a critical Csingle bondC bond forming enzyme, α-oxoamine synthase …
Visualizing the interface of biotin and fatty acid biosynthesis through SuFEx probes
Site-specific covalent conjugation offers a powerful tool to identify and understand protein–
protein interactions. In this study, we discover that sulfur fluoride exchange (SuFEx) …
protein interactions. In this study, we discover that sulfur fluoride exchange (SuFEx) …
N-to-S Acyl Transfer as an Enabling Strategy in Asymmetric and Chemoenzymatic Synthesis
The observation of thioester-mediated acyl transfer processes in nature has inspired the
development of novel protein synthesis and functionalization methodologies. The …
development of novel protein synthesis and functionalization methodologies. The …
Exploring the Structure–Function Relationships in a 5-Aminolevulinic Acid Synthase and the Use of Protein Engineering to Expand its Substrate Range
A Kim, JD Stewart - Biochemistry, 2025 - ACS Publications
5-Aminolevulinate synthase (ALAS) is a PLP-dependent enzyme that catalyzes the
production of 5-aminolevulinate from succinyl-CoA and glycine. Its ability to catalyze the …
production of 5-aminolevulinate from succinyl-CoA and glycine. Its ability to catalyze the …
Substrate-selective catalysis enabled synthesis of azaphilone natural products
Achieving substrate-selectivity is a central element of nature's approach to synthesis. By
relying on the ability of a catalyst to discriminate between components in a mixture, control …
relying on the ability of a catalyst to discriminate between components in a mixture, control …
Rational Engineering of a Thermostable α-Oxoamine Synthase Biocatalyst Expands the Substrate Scope and Synthetic Applicability
D Campopiano, B Ashley, Y Zhu, S Mathew, M Sajjad… - 2024 - researchsquare.com
Carbon-carbon bond formation is one of the key pillars of organic synthesis. Green, selective
and efficient biocatalytic methods for such are therefore highly desirable. The α-oxoamine …
and efficient biocatalytic methods for such are therefore highly desirable. The α-oxoamine …
Decoding Novel Metabolic Functions and Binding Products of Human Aldo-Keto Reductase 1C3
N Dudkina - 2024 - search.proquest.com
The increased incidents of many chronic diseases such as asthma, allergies, diabetes, heart
disease, and mental disorders cannot be fully explained by genetic factors. The exposure to …
disease, and mental disorders cannot be fully explained by genetic factors. The exposure to …