[HTML][HTML] Resveratrol for cancer therapy: Challenges and future perspectives

B Ren, MXY Kwah, C Liu, Z Ma, MK Shanmugam… - Cancer letters, 2021 - Elsevier
Abstract Resveratrol (3, 4', 5-trihydroxy-trans-stilbene) has been expected to ameliorate
cancer and foster breakthroughs in cancer therapy. Despite thousands of preclinical studies …

Bioactivity of dietary polyphenols: The role of metabolites

SV Luca, I Macovei, A Bujor, A Miron… - Critical reviews in …, 2020 - Taylor & Francis
A polyphenol-rich diet protects against chronic pathologies by modulating numerous
physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation …

Polymeric nanoparticles for delivery of natural bioactive agents: recent advances and challenges

M Elmowafy, K Shalaby, MH Elkomy, OA Alsaidan… - Polymers, 2023 - mdpi.com
In the last few decades, several natural bioactive agents have been widely utilized in the
treatment and prevention of many diseases owing to their unique and versatile therapeutic …

[HTML][HTML] The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy

C Grinán-Ferré, A Bellver-Sanchis, V Izquierdo… - Ageing Research …, 2021 - Elsevier
While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review

T Teka, L Zhang, X Ge, Y Li, L Han, X Yan - Phytochemistry, 2022 - Elsevier
Stilbenes are some of the important phenolic compounds originating from plant families like
Vitaceae, Leguminaceae, Gnetaceae, and Dipterocarpaceae. Structurally, they have a C6 …

Health benefits of resveratrol: Evidence from clinical studies

AP Singh, R Singh, SS Verma, V Rai… - Medicinal research …, 2019 - Wiley Online Library
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

M Agrawal, S Saraf, S Saraf, SG Antimisiaris… - Journal of controlled …, 2018 - Elsevier
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …

Biopolymer nano-particles and natural nano-carriers for nano-encapsulation of phenolic compounds

AF Esfanjani, SM Jafari - Colloids and Surfaces B: Biointerfaces, 2016 - Elsevier
Phenolic compounds are major micronutrients in our diet, 1 and evidence for their role in the
prevention of degenerative diseases such as cancer, inflammation and neurodegenerative …

[HTML][HTML] Progress to improve oral bioavailability and beneficial effects of resveratrol

A Chimento, F De Amicis, R Sirianni… - International journal of …, 2019 - mdpi.com
Resveratrol (3, 5, 4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present
in many species of plants, particularly in grapes, blueberries, and peanuts. Several in vitro …

The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB-mediated inflammation

HA Saleh, MH Yousef, A Abdelnaser - Frontiers in immunology, 2021 - frontiersin.org
Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …