Beyond its remarkable genome editing ability, the CRISPR/Cas9 effector has also been
utilized in biosensing applications. The recent discovery of the collateral RNA cleavage …

The application of clustered regularly interspaced short palindromic repeats (CRISPR) for
genetic manipulation has revolutionized life science over the past few years. CRISPR was …

RNA-guided CRISPR activation (CRISPRa) systems have been developed in plants.
However, the simultaneous activation of multiple genes remains challenging. Here, we …

Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

Since late December 2019, the coronavirus pandemic (COVID-19; previously known as
2019-nCoV) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Rapidly developing technologies have recently fueled an exciting era of discovery in the
field of chromosome structure and nuclear organization. In addition to chromosome …

RNA-binding proteins (RBPs) play an essential role in regulating the function of RNAs in a
cellular context, but our ability to control RBP activity in time and space is limited. Here, we …

CRISPR-Cas adaptive immune systems in bacteria and archaea utilize short CRISPR RNAs
(crRNAs) to guide sequence-specific recognition and clearance of foreign genetic material …

Expansion of an intronic (GGGGCC) n repeat within the C9ORF72 gene is the most common
genetic cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis …

Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …