The mechanism of HMGB1 secretion and release

R Chen, R Kang, D Tang - Experimental & molecular medicine, 2022 - nature.com
High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

Notch signaling in acute inflammation and sepsis

N Gallenstein, L Tichy, MA Weigand… - International Journal of …, 2023 - mdpi.com
Notch signaling, a highly conserved pathway in mammals, is crucial for differentiation and
homeostasis of immune cells. Besides, this pathway is also directly involved in the …

Modulation of macrophage polarization by viruses: turning off/on host antiviral responses

S Yu, H Ge, S Li, HJ Qiu - Frontiers in microbiology, 2022 - frontiersin.org
Macrophages are professional antigen-presenting cells and serve as the first line of defense
against invading pathogens. Macrophages are polarized toward the proinflammatory …

Impact of structural features of acetylated bacterial cellulose on cell-scaffold and scaffold-blood interactions in vitro

MW Ullah, F Subhan, S Manan, M Ul-Islam… - Cellulose, 2023 - Springer
This study aimed to determine the effect of the structural properties of acetylated bacterial
cellulose (ABC) on its in vitro biological performance. Acetylation resulted in several …

Notch signaling pathway: a new target for neuropathic pain therapy

Y Zhang, T Wang, S Wu, L Tang, J Wang… - The Journal of …, 2023 - Springer
The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110
years ago and has been found to play a crucial role in the development of multicellular …

Targeting different signaling pathways for food allergy regulation and potential therapy: a review

H Zhong, J Li, JH Cheng - Critical Reviews in Food Science and …, 2024 - Taylor & Francis
The rising incidence rate of food allergy is attracting more intention. The pathogenesis of
food allergy is complex and its definite regulatory mechanism is not utterly understood …

Molecular regulation after mucosal injury and regeneration in ulcerative colitis

L Zheng, SL Duan, XL Wen, YC Dai - Frontiers in Molecular …, 2022 - frontiersin.org
Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with a complex etiology.
Intestinal mucosal injury is an important pathological change in individuals with UC. Leucine …

[HTML][HTML] Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

L Zheng, SL Duan - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes.
The main pathological changes were intestinal mucosal injury. Leucine-rich repeat …

Olfactory bulb neurogenesis depending on signaling in the subventricular zone

Y Chen, P Ren, X He, F Yan, R Gu, J Bai… - Cerebral …, 2023 - academic.oup.com
Olfaction is a crucial sense that is essential for the well-being and survival of individuals.
Olfactory bulb (OB) is the first olfactory relay station, and its function depends on newly …

Ganoderma atrum polysaccharide modulates the M1/M2 polarization of macrophages linked to the Notch signaling pathway

T Li, YS Zhang, M Wan, W Wu, YF Yao, WJ Li - Food & Function, 2022 - pubs.rsc.org
Macrophages could be polarized into two major sub-populations including classically
activated (M1) and alternatively activated (M2) macrophages. The present study aimed to …