Mass spectrometry is a vital tool for molecular characterization, and the allied technique of
ion mobility is enhancing many areas of (bio) chemical analysis. Strong synergy arises …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

Collision cross section (CCS, Ω) values determined by ion mobility mass spectrometry (IM-
MS) provide the study of ion shape in the gas phase and use of these as further identification …

Besides the well-known DNA double-helix, non-canonical nucleic acid structures regulate
crucial biological activities. Among these oddities, guanine-rich DNA sequences can form …

All processes that occur within living organisms are intimately linked to biological
macromolecules such as proteins, nucleic acids, or polysaccharides. Phospholipid …

Currently, the vast majority of complex carbohydrates are characterized using mass
spectrometry (MS)-based techniques. Measuring the molecular mass of a sugar, however …

Hexafluoroisopropanol (HFIP) has been widely used as an acidic modifier for mobile phases
for liquid chromatography-mass spectrometry (LC-MS) analysis of oligonucleotides ever …

Glycosylation is one of the most common post-translational modifications occurring in
proteins. A detailed structural characterization of the involved carbohydrates, however, is still …

The advancement of CRISPR-based gene editing tools into biotherapeutics offers the
potential for cures to genetic disorders and for new treatment paradigms for even common …