The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes
develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin …

Insulin is a life-saving drug for patients with type 1 diabetes; however, even today, no
pharmacotherapy can prevent the loss or dysfunction of pancreatic insulin-producing β cells …

Human pancreatic plasticity is implied from multiple single-cell RNA sequencing (scRNA-
seq) studies. However, these have been invariably based on static datasets from which fate …

Abstract Type 2 diabetes (T2D) is associated with β-cell dedifferentiation. Aldehyde
dehydrogenase 1 isoform A3 (ALHD1A3) is a marker of β-cell dedifferentiation and …

Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental
challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase …

Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases
(CLKs) recently attracted attention due to their central involvement in various pathologies …

Preservation and expansion of β-cell mass is a therapeutic goal for diabetes. Here we show
that the hyperactive isoform of carbohydrate response-element binding protein (ChREBPβ) …

Cell replacement therapy using stem-cell-derived insulin-producing β-like cells (sBCs) has
been proposed as a practical cure for patients with type one diabetes (T1D). sBCs can …

Type 1 diabetes (T1D) is an incurable condition with an increasing incidence worldwide, in
which the hallmark is the autoimmune destruction of pancreatic insulin-producing β cells …

The rising prevalence of diabetes is threatening global health. It is known not only for the
occurrence of severe complications but also for the SARS-Cov-2 pandemic, which shows …