The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in
nervous tissue from early embryonic life. They also cross the blood brain barriers by active …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a polyglutamine expansion mutation in the huntingtin protein. Expansions above 40 …

Huntington's disease is associated with a reactive microglial response and consequent
inflammation. To address the role of these cells in disease pathogenesis, we depleted …

Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases,
highlighting alterations in the function of the endoplasmic reticulum (ER). We previously …

Initially characterized for their roles in apoptosis, executioner caspases have emerged as
important regulators of an array of cellular activities. This is especially true in the nervous …

Caspases are a family of cysteine proteases that predominantly cleave their substrates after
aspartic acid residues. Much of what we know of caspases emerged from investigation a …

Caspases are a family of cysteine-dependent proteases with important cellular functions in
inflammation and apoptosis, while also implicated in human diseases. Classical chemical …

Increasing evidence supports a role for abnormal immune activation and inflammatory
responses in Huntington disease (HD). In this study, we evaluated the therapeutic potential …

Expanded polyglutamine (polyQ) stretches in at least nine unrelated proteins lead to
inherited neuronal dysfunction and degeneration. The expansion size in all diseases …

Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder
which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated …