The evolution and biology of SARS-CoV-2 variants
A Telenti, EB Hodcroft… - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Our understanding of the still unfolding severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) pandemic would have been extremely limited without the study of the …
(SARS-CoV-2) pandemic would have been extremely limited without the study of the …
The impact of evolving SARS-CoV-2 mutations and variants on COVID-19 vaccines
The emergence of several new variants of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in recent months has raised concerns around the potential impact on …
(SARS-CoV-2) in recent months has raised concerns around the potential impact on …
Deep-learning-enabled protein–protein interaction analysis for prediction of SARS-CoV-2 infectivity and variant evolution
G Wang, X Liu, K Wang, Y Gao, G Li… - Nature Medicine, 2023 - nature.com
Host–pathogen interactions and pathogen evolution are underpinned by protein–protein
interactions between viral and host proteins. An understanding of how viral variants affect …
interactions between viral and host proteins. An understanding of how viral variants affect …
[HTML][HTML] Learning from prepandemic data to forecast viral escape
Effective pandemic preparedness relies on anticipating viral mutations that are able to
evade host immune responses to facilitate vaccine and therapeutic design. However, current …
evade host immune responses to facilitate vaccine and therapeutic design. However, current …
GenSLMs: Genome-scale language models reveal SARS-CoV-2 evolutionary dynamics
We seek to transform how new and emergent variants of pandemic-causing viruses,
specifically SARS-CoV-2, are identified and classified. By adapting large language models …
specifically SARS-CoV-2, are identified and classified. By adapting large language models …
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants
E Volz - Nature Reviews Genetics, 2023 - nature.com
The massive scale of the global SARS-CoV-2 sequencing effort created new opportunities
and challenges for understanding SARS-CoV-2 evolution. Rapid detection and assessment …
and challenges for understanding SARS-CoV-2 evolution. Rapid detection and assessment …
Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T cell immunity
Evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
variant has led to the emergence of sublineages with different patterns of neutralizing …
variant has led to the emergence of sublineages with different patterns of neutralizing …
Predicting the antigenic evolution of SARS-COV-2 with deep learning
The relentless evolution of SARS-CoV-2 poses a significant threat to public health, as it
adapts to immune pressure from vaccines and natural infections. Gaining insights into …
adapts to immune pressure from vaccines and natural infections. Gaining insights into …
Interpretable and predictive deep neural network modeling of the SARS-Cov-2 spike protein sequence to predict COVID-19 disease severity
BA Sokhansanj, Z Zhao, GL Rosen - Biology, 2022 - mdpi.com
Simple Summary As COVID-19 shifts from pandemic to endemic, emerging variants may be
more or less virulent. Predicting whether an emerging COVID-19 variant has of high risk of …
more or less virulent. Predicting whether an emerging COVID-19 variant has of high risk of …
Mechanistic study of the transmission pattern of the SARS‐CoV‐2 omicron variant
The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
characterized by 30 mutations in its spike protein, has rapidly spread worldwide since …
characterized by 30 mutations in its spike protein, has rapidly spread worldwide since …