Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks

A Wadhwa, M Moreno-Villanueva, B Crucian, H Wu - Immunity & Ageing, 2024 - Springer
Spaceflight poses a myriad of environmental stressors to astronauts´ physiology including
microgravity and radiation. The individual impacts of microgravity and radiation on the …

Thymus ad astra, or spaceflight-induced thymic involution

W Muramatsu, M Maryanovich, T Akiyama… - Frontiers in …, 2025 - frontiersin.org
Spaceflight imposes a constellation of physiological challenges—cosmic radiation,
microgravity, disrupted circadian rhythms, and psychosocial stress—that critically …

Omics Studies of Tumor Cells under Microgravity Conditions

J Graf, H Schulz, M Wehland, TJ Corydon… - International Journal of …, 2024 - mdpi.com
Cancer is defined as a group of diseases characterized by abnormal cell growth, expansion,
and progression with metastasis. Various signaling pathways are involved in its …

[HTML][HTML] Radiation-Induced Brain Injury: Mechanistic Insights and the Promise of Gut–Brain Axis Therapies

M Li, F Tong, B Wu, X Dong - Brain Sciences, 2024 - mdpi.com
Radiation therapy is widely recognized as an efficacious modality for treating neoplasms
located within the craniofacial region. Nevertheless, this approach is not devoid of risks …

Organs in orbit: how tissue chip technology benefits from microgravity, a perspective

A Jogdand, M Landolina, Y Chen - Frontiers in Lab on a Chip …, 2024 - frontiersin.org
Tissue chips have become one of the most potent research tools in the biomedical field. In
contrast to conventional research methods, such as 2D cell culture and animal models …

A computational model of altered neuronal activity in altered gravity

C Gontier, L Kalinski, J Striebel, M Sturm, Z Meerholz… - bioRxiv, 2024 - biorxiv.org
Electrophysiological experiments have shown that neuronal activity changes upon exposure
to altered gravity. More specifically, the firing rate increases during microgravity and …

An end-to-end pipeline to study and model proton radiation-induced effects of the central nervous system as a function of dose and linear energy transfer at the single …

MO Boucsein - 2024 - archiv.ub.uni-heidelberg.de
Proton therapy is a promising form of brain radiotherapy due to its characteristic Bragg peak
profile sparing normal tissue. However, late side effects have been observed and the …

Biomarkers of ionising radiation relevant to carcinogenesis: Dose, dose rate and LET dependency of the responses

M López Riego - 2023 - diva-portal.org
A better understanding of the relationship between ionising radiation (IR) dose, dose rate
and radiation quality, and the risk of stochastic effects would improve risk extrapolation from …

[PDF][PDF] Geriatric Space Travel©

GM Caswell - Int J Geriatr Gerontol, 2023 - spaceportaustralia.com.au
The world community continues to move towards exploring the solar system, with
exploration of our immediate solar system aimed at establishing intra-planetary colonies …