The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

As medical and pharmacological technology advances, new and complex modalities of
disease treatment that are more personalized and targeted are being developed. Often …

The hypoxic tumor microenvironment has been implicated in immune escape, but the
underlying mechanism remains elusive. Using an in vitro culture system modeling human T …

Atopic dermatitis (AD) is a common chronic pruritic inflammatory skin disorder characterized
by recurrent eczematous lesions. Interleukin (IL)− 33, a cytokine of the IL-1 family, was found …

In recent decades, chimeric antigen receptor (CAR)–engineered immune effector cells have
demonstrated promising antileukemic activity. Nevertheless, their efficacy remains …

Ferroptosis is a type of iron-dependent cell death pertaining to an excess of lipid
peroxidation. It has been suggested that sorafenib—an anti-angiogenic medication for …

Breakthroughs in cancer treatment with immunotherapeutics have provided long‐term
patient benefits for many different types of cancer. However, complete response is not …

Abstract Interleukin-33 (IL-33)(NF-HEV), a chromatin-associated nuclear cytokine, is a
member of the IL-1 family. IL-33 possesses a nuclear localization signal and a …

Cancer therapeutics have undergone immense research over the past decade. While
chemotherapies remain the mainstay treatments for many cancers, the advent of new …

In solid tumors, the exhaustion of natural killer (NK) cells and cytotoxic T cells in the
immunosuppressive tumor microenvironment poses challenges for effective tumor control …