Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction
Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence
suggests that characteristic differences are present in the nuclear mechanics and …
suggests that characteristic differences are present in the nuclear mechanics and …
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues
Fibrillar proteins are principal components of extracellular matrix (ECM) that confer
mechanical properties to tissues. Fibrosis can result from wound repair in nearly every tissue …
mechanical properties to tissues. Fibrosis can result from wound repair in nearly every tissue …
Lamins: The backbone of the nucleocytoskeleton interface
The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and
consists of lamin filaments and associated proteins. Lamins are type V intermediate filament …
consists of lamin filaments and associated proteins. Lamins are type V intermediate filament …
Nuclear mechanoprotection: From tissue atlases as blueprints to distinctive regulation of nuclear lamins
Two meters of DNA in each of our cells must be protected against many types of damage.
Mechanoprotection is increasingly understood to be conferred by the nuclear lamina of …
Mechanoprotection is increasingly understood to be conferred by the nuclear lamina of …
Stiffness-dependent MSC homing and differentiation into CAFs–implications for breast cancer invasion
Cellular heterogeneity and extracellular matrix (ECM) stiffening have been shown to be
drivers of breast cancer invasiveness. Here, we examine how stiffness-dependent crosstalk …
drivers of breast cancer invasiveness. Here, we examine how stiffness-dependent crosstalk …
Deleterious mechanical deformation selects mechanoresilient cancer cells with enhanced proliferation and chemoresistance
Cancer cells in secondary tumors are found to form metastases more efficiently as compared
to their primary tumor counterparts. This is partially due to the unfavorable …
to their primary tumor counterparts. This is partially due to the unfavorable …
Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate
Nuclear rupture has long been associated with deficits or defects in lamins, with recent
results also indicating a role for actomyosin stress, but key physical determinants of rupture …
results also indicating a role for actomyosin stress, but key physical determinants of rupture …
Coordinated in confined migration: crosstalk between the nucleus and ion channel-mediated mechanosensation
Cell surface and intracellular mechanosensors enable cells to perceive different geometric,
topographical, and physical cues. Mechanosensitive ion channels (MICs) localized at the …
topographical, and physical cues. Mechanosensitive ion channels (MICs) localized at the …
Forces in stem cells and cancer stem cells
F Chowdhury, B Huang, N Wang - Cells & development, 2022 - Elsevier
Endogenous and exogenous forces are critical in physiology and pathology of the human
body. Increasing evidence suggests that these forces, mechanics, and force-associated …
body. Increasing evidence suggests that these forces, mechanics, and force-associated …
Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation
Y Zhang, Q Dong, Q An, C Zhang… - Advanced …, 2022 - Wiley Online Library
A recently developed synthetic retinoid abrogates proliferation and induces apoptosis of
drug‐resistant malignant‐cancer‐stem‐cell‐like cells. However, the underlying mechanisms …
drug‐resistant malignant‐cancer‐stem‐cell‐like cells. However, the underlying mechanisms …