Pain is the primary motivation for seeking medical care. Although pain may subside as
inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain …

Fibromyalgia is a debilitating widespread chronic pain syndrome that occurs in 2 to 4% of
the population. The prevailing view that fibromyalgia results from central nervous system …

We aimed to investigate a sexually dimorphic role of calcitonin gene-related peptide (CGRP)
in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain …

Post-exercise recovery is essential to resolve metabolic perturbations and promote long-
term cellular remodeling in response to exercise. Here, we report that muscle-generated …

An estimated 10%–50% of patients undergoing a surgical intervention will develop
persistent postsurgical pain (PPP) lasting more than 3 months despite adequate acute pain …

Despite the overwhelming female-predominance in chronic pain disorders, preclinical pain
studies have historically excluded females as research subjects. Male-biased explanations …

1. Background Quality of life of patients with head and neck cancer (HNC) is notoriously
poor because of the greater prevalence of pain compared with other cancer types. 15, 42 …

Dorsal root ganglia (DRG) neurons have been well described for their role in driving both
acute and chronic pain. Although nerve injury is known to cause transcriptional …

Circulating monocytes participate in pain chronification but the molecular events that cause
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …

The introduction of sex-as-a-biological-variable policies at funding agencies around the
world has led to an explosion of very recent observations of sex differences in the biology …